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Systemic immunosuppression promotes survival and integration of subretinally implanted human ESC-derived photoreceptor precursors in dogs.
Ripolles-Garcia A, Dolgova N, Phillips MJ, Savina S, Ludwig AL, Stuedemann SA, Nlebedum U, Wolfe JH, Garden OA, Maminishkis A, Amaral J, Bharti K, Gamm DM, Aguirre GD, Beltran WA. Ripolles-Garcia A, et al. Stem Cell Reports. 2022 Aug 9;17(8):1824-1841. doi: 10.1016/j.stemcr.2022.06.009. Epub 2022 Jul 28. Stem Cell Reports. 2022. PMID: 35905738 Free PMC article.
Targeting ON-bipolar cells by AAV gene therapy stably reverses LRIT3-congenital stationary night blindness.
Miyadera K, Santana E, Roszak K, Iffrig S, Visel M, Iwabe S, Boyd RF, Bartoe JT, Sato Y, Gray A, Ripolles-Garcia A, Dufour VL, Byrne LC, Flannery JG, Beltran WA, Aguirre GD. Miyadera K, et al. Among authors: ripolles garcia a. Proc Natl Acad Sci U S A. 2022 Mar 29;119(13):e2117038119. doi: 10.1073/pnas.2117038119. Epub 2022 Mar 22. Proc Natl Acad Sci U S A. 2022. PMID: 35316139 Free PMC article.
Gene therapy reforms photoreceptor structure and restores vision in NPHP5-associated Leber congenital amaurosis.
Aguirre GD, Cideciyan AV, Dufour VL, Ripolles-García A, Sudharsan R, Swider M, Nikonov R, Iwabe S, Boye SL, Hauswirth WW, Jacobson SG, Beltran WA. Aguirre GD, et al. Among authors: ripolles garcia a. Mol Ther. 2021 Dec 1;29(12):3528. doi: 10.1016/j.ymthe.2021.10.021. Epub 2021 Oct 29. Mol Ther. 2021. PMID: 34715016 Free PMC article. No abstract available.