Guida W - Search Results

1

Helical sulfonyl-γ-AApeptides modulating Aβ oligomerization and cytotoxicity by recognizing Aβ helix.

Liu H, Cui Y, Zhao X, Wei L, Wang X, Shen N, Odom T, Li X, Lawless W, Karunarathne K, Muschol M, Guida W, Cao C, Ye L, Cai J. Liu H, et al. Among authors: guida w. Proc Natl Acad Sci U S A. 2024 Feb 6;121(6):e2311733121. doi: 10.1073/pnas.2311733121. Epub 2024 Jan 29. Proc Natl Acad Sci U S A. 2024. PMID: 38285951

2

Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity.

Siddiquee K, Zhang S, Guida WC, Blaskovich MA, Greedy B, Lawrence HR, Yip ML, Jove R, McLaughlin MM, Lawrence NJ, Sebti SM, Turkson J. Siddiquee K, et al. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7391-6. doi: 10.1073/pnas.0609757104. Epub 2007 Apr 26. Proc Natl Acad Sci U S A. 2007. PMID: 17463090 Free PMC article.

3

Circular permutation of 5-aminolevulinate synthase: effect on folding, conformational stability, and structure.

Cheltsov AV, Guida WC, Ferreira GC. Cheltsov AV, et al. J Biol Chem. 2003 Jul 25;278(30):27945-55. doi: 10.1074/jbc.M207011200. Epub 2003 May 7. J Biol Chem. 2003. PMID: 12736261 Free article.

4

Ligand-mediated protein degradation reveals functional conservation among sequence variants of the CUL4-type E3 ligase substrate receptor cereblon.

Akuffo AA, Alontaga AY, Metcalf R, Beatty MS, Becker A, McDaniel JM, Hesterberg RS, Goodheart WE, Gunawan S, Ayaz M, Yang Y, Karim MR, Orobello ME, Daniel K, Guida W, Yoder JA, Rajadhyaksha AM, Schönbrunn E, Lawrence HR, Lawrence NJ, Epling-Burnette PK. Akuffo AA, et al. Among authors: guida w. J Biol Chem. 2018 Apr 20;293(16):6187-6200. doi: 10.1074/jbc.M117.816868. Epub 2018 Feb 15. J Biol Chem. 2018. PMID: 29449372 Free PMC article.

5

Cardioprotective Effects of 1-(3,6-Dibromo-carbazol-9-yl)-3-Phenylamino-Propan-2-Ol in Diabetic Hearts via Nicotinamide Phosphoribosyltransferase Activation.

Tur J, Badole SL, Manickam R, Chapalamadugu KC, Xuan W, Guida W, Crews JJ, Bisht KS, Tipparaju SM. Tur J, et al. Among authors: guida w. J Pharmacol Exp Ther. 2022 Aug;382(2):233-245. doi: 10.1124/jpet.122.001122. Epub 2022 Jun 9. J Pharmacol Exp Ther. 2022. PMID: 35680376 Free PMC article.

6

Facile iterative synthesis of 2,5-terpyrimidinylenes as nonpeptidic alpha-helical mimics.

Anderson L, Zhou M, Sharma V, McLaughlin JM, Santiago DN, Fronczek FR, Guida WC, McLaughlin ML. Anderson L, et al. J Org Chem. 2010 Jun 18;75(12):4288-91. doi: 10.1021/jo100272d. J Org Chem. 2010. PMID: 20469918 Free PMC article.

7

Inhibition of cellular Shp2 activity by a methyl ester analog of SPI-112.

Chen L, Pernazza D, Scott LM, Lawrence HR, Ren Y, Luo Y, Wu X, Sung SS, Guida WC, Sebti SM, Lawrence NJ, Wu J. Chen L, et al. Biochem Pharmacol. 2010 Sep 15;80(6):801-10. doi: 10.1016/j.bcp.2010.05.019. Epub 2010 May 25. Biochem Pharmacol. 2010. PMID: 20510203 Free PMC article.

8

A specific small-molecule inhibitor of protein kinase CδI activity improves metabolic dysfunction in human adipocytes from obese individuals.

Sparks R, Lui A, Bader D, Patel R, Murr M, Guida W, Fratti R, Patel NA. Sparks R, et al. Among authors: guida w. J Biol Chem. 2019 Oct 11;294(41):14896-14910. doi: 10.1074/jbc.RA119.008777. Epub 2019 Aug 14. J Biol Chem. 2019. PMID: 31413114 Free PMC article.

9

Identification of a new binding site in E. coli FabH using Molecular dynamics simulations: validation by computational alanine mutagenesis and docking studies.

Ramamoorthy D, Turos E, Guida WC. Ramamoorthy D, et al. J Chem Inf Model. 2013 May 24;53(5):1138-56. doi: 10.1021/ci3003528. Epub 2013 Apr 15. J Chem Inf Model. 2013. PMID: 23581389

10

β-Strand mimics based on tetrahydropyridazinedione (tpd) peptide stitching.

Kang CW, Sarnowski MP, Ranatunga S, Wojtas L, Metcalf RS, Guida WC, Del Valle JR. Kang CW, et al. Chem Commun (Camb). 2015 Nov 21;51(90):16259-62. doi: 10.1039/c5cc07189e. Chem Commun (Camb). 2015. PMID: 26400240 Free PMC article.

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