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BI-3231, an enzymatic inhibitor of HSD17B13, reduces lipotoxic effects induced by palmitic acid in murine and human hepatocytes.
Alcober-Boquet L, Kraus N, Huber LS, Vutukuri R, Fuhrmann DC, Stross C, Schaefer L, Scholich K, Zeuzem S, Piiper A, Schulz MH, Trebicka J, Welsch C, Ortiz C. Alcober-Boquet L, et al. Among authors: ortiz c. Am J Physiol Cell Physiol. 2024 Mar 1;326(3):C880-C892. doi: 10.1152/ajpcell.00413.2023. Epub 2024 Jan 15. Am J Physiol Cell Physiol. 2024. PMID: 38223924
Neprilysin-dependent neuropeptide Y cleavage in the liver promotes fibrosis by blocking NPY-receptor 1.
Ortiz C, Klein S, Reul WH, Magdaleno F, Gröschl S, Dietrich P, Schierwagen R, Uschner FE, Torres S, Hieber C, Meier C, Kraus N, Tyc O, Brol M, Zeuzem S, Welsch C, Poglitsch M, Hellerbrand C, Alfonso-Prieto M, Mira F, Keller UAD, Tetzner A, Moore A, Walther T, Trebicka J. Ortiz C, et al. Cell Rep. 2023 Feb 28;42(2):112059. doi: 10.1016/j.celrep.2023.112059. Epub 2023 Jan 31. Cell Rep. 2023. PMID: 36729833 Free PMC article.
The non-selective Rho-kinase inhibitors Y-27632 and Y-33075 decrease contraction but increase migration in murine and human hepatic stellate cells.
Bachtler N, Torres S, Ortiz C, Schierwagen R, Tyc O, Hieber C, Berres ML, Meier C, Kraus N, Zeuzem S, Nijmeijer B, Pronk S, Trebicka J, Klein S. Bachtler N, et al. Among authors: ortiz c. PLoS One. 2023 Jan 31;18(1):e0270288. doi: 10.1371/journal.pone.0270288. eCollection 2023. PLoS One. 2023. PMID: 36719899 Free PMC article.
Extracellular Matrix Remodeling in Chronic Liver Disease.
Ortiz C, Schierwagen R, Schaefer L, Klein S, Trepat X, Trebicka J. Ortiz C, et al. Curr Tissue Microenviron Rep. 2021;2(3):41-52. doi: 10.1007/s43152-021-00030-3. Epub 2021 Jul 23. Curr Tissue Microenviron Rep. 2021. PMID: 34337431 Free PMC article. Review.
Janus kinase 2 inhibition by pacritinib as potential therapeutic target for liver fibrosis.
Torres S, Ortiz C, Bachtler N, Gu W, Grünewald LD, Kraus N, Schierwagen R, Hieber C, Meier C, Tyc O, Joseph Brol M, Uschner FE, Nijmeijer B, Welsch C, Berres ML, Garcia-Ruiz C, Fernandez-Checa JC, Trautwein C, Vogl TJ, Zeuzem S, Trebicka J, Klein S. Torres S, et al. Among authors: ortiz c. Hepatology. 2023 Apr 1;77(4):1228-1240. doi: 10.1002/hep.32746. Epub 2022 Oct 13. Hepatology. 2023. PMID: 35993369 Free PMC article.
The Role of Macrophage-Inducible C-Type Lectin in Different Stages of Chronic Liver Disease.
Schierwagen R, Uschner FE, Ortiz C, Torres S, Brol MJ, Tyc O, Gu W, Grimm C, Zeuzem S, Plamper A, Pfeifer P, Zimmer S, Welsch C, Schaefer L, Rheinwalt KP, Clària J, Arroyo V, Trebicka J, Klein S. Schierwagen R, et al. Among authors: ortiz c. Front Immunol. 2020 Jul 7;11:1352. doi: 10.3389/fimmu.2020.01352. eCollection 2020. Front Immunol. 2020. PMID: 32733451 Free PMC article.
Variation in Bile Microbiome by the Etiology of Cholestatic Liver Disease.
Tyc O, Jansen C, Schierwagen R, Uschner FE, Israelsen M, Klein S, Ortiz C, Strassburg CP, Zeuzem S, Gu W, Torres S, Praktiknjo M, Kersting S, Langheinrich M, Nattermann J, Servant F, Arumugam M, Krag A, Lelouvier B, Weismüller TJ, Trebicka J. Tyc O, et al. Among authors: ortiz c. Liver Transpl. 2020 Dec;26(12):1652-1657. doi: 10.1002/lt.25882. Epub 2020 Oct 7. Liver Transpl. 2020. PMID: 32885580 Free PMC article. No abstract available.
The Specific NLRP3 Antagonist IFM-514 Decreases Fibrosis and Inflammation in Experimental Murine Non-Alcoholic Steatohepatitis.
Torres S, Brol MJ, Magdaleno F, Schierwagen R, Uschner FE, Klein S, Ortiz C, Tyc O, Bachtler N, Stunden J, Bertheloot D, Kitanovic A, Sanchez B, Schrum J, Roush WR, Franchi L, Byth K, Latz E, Trebicka J. Torres S, et al. Among authors: ortiz c. Front Mol Biosci. 2021 Aug 13;8:715765. doi: 10.3389/fmolb.2021.715765. eCollection 2021. Front Mol Biosci. 2021. PMID: 34513923 Free PMC article.
927 results