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A novel ARPKD mouse model with near-complete deletion of the Polycystic Kidney and Hepatic Disease 1 (Pkhd1) genomic locus presents with multiple phenotypes but not renal cysts.
Ishimoto Y, Menezes LF, Zhou F, Yoshida T, Komori T, Qiu J, Young MF, Lu H, Potapova S, Outeda P, Watnick T, Germino GG. Ishimoto Y, et al. Among authors: zhou f. Kidney Int. 2023 Sep;104(3):611-616. doi: 10.1016/j.kint.2023.05.027. Epub 2023 Jul 5. Kidney Int. 2023. PMID: 37419448 No abstract available.
Pkd1 and Pkd2 are required for normal placental development.
Garcia-Gonzalez MA, Outeda P, Zhou Q, Zhou F, Menezes LF, Qian F, Huso DL, Germino GG, Piontek KB, Watnick T. Garcia-Gonzalez MA, et al. Among authors: zhou f, zhou q. PLoS One. 2010 Sep 16;5(9):e12821. doi: 10.1371/journal.pone.0012821. PLoS One. 2010. PMID: 20862291 Free PMC article.
A cleavage product of Polycystin-1 is a mitochondrial matrix protein that affects mitochondria morphology and function when heterologously expressed.
Lin CC, Kurashige M, Liu Y, Terabayashi T, Ishimoto Y, Wang T, Choudhary V, Hobbs R, Liu LK, Lee PH, Outeda P, Zhou F, Restifo NP, Watnick T, Kawano H, Horie S, Prinz W, Xu H, Menezes LF, Germino GG. Lin CC, et al. Among authors: zhou f. Sci Rep. 2018 Feb 9;8(1):2743. doi: 10.1038/s41598-018-20856-6. Sci Rep. 2018. PMID: 29426897 Free PMC article.
In vivo Polycystin-1 interactome using a novel Pkd1 knock-in mouse model.
Lin CC, Menezes LF, Qiu J, Pearson E, Zhou F, Ishimoto Y, Anderson DE, Germino GG. Lin CC, et al. Among authors: zhou f. PLoS One. 2023 Aug 4;18(8):e0289778. doi: 10.1371/journal.pone.0289778. eCollection 2023. PLoS One. 2023. PMID: 37540694 Free PMC article.
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