A novel ARPKD mouse model with near-complete deletion of the Polycystic Kidney and Hepatic Disease 1 (Pkhd1) genomic locus presents with multiple phenotypes but not renal cysts

Affiliations

• ¹ Polycystic Kidney Disease Section, Kidney Disease Branch, National Institute of Diabetes and Digestive and Kidney Disease (NIDDK), National Institutes of Health (NIH), Bethesda, Maryland, USA.
• ² Polycystic Kidney Disease Section, Kidney Disease Branch, National Institute of Diabetes and Digestive and Kidney Disease (NIDDK), National Institutes of Health (NIH), Bethesda, Maryland, USA. Electronic address: luis.menezes@nih.gov.
• ³ Molecular Biology of Bones and Teeth Section, Department of Health and Human Services (DHHS), National Institutes of Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH), Bethesda, Maryland, USA.
• ⁴ Mouse Transgenic Core Facility, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH), Bethesda, Maryland, USA.
• ⁵ Division of Nephrology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
• ⁶ Polycystic Kidney Disease Section, Kidney Disease Branch, National Institute of Diabetes and Digestive and Kidney Disease (NIDDK), National Institutes of Health (NIH), Bethesda, Maryland, USA. Electronic address: gregory.germino@nih.gov.