Guy RK - Search Results

1

Proteasome inhibition targets the KMT2A transcriptional complex in acute lymphoblastic leukemia.

Kamens JL, Nance S, Koss C, Xu B, Cotton A, Lam JW, Garfinkle EAR, Nallagatla P, Smith AMR, Mitchell S, Ma J, Currier D, Wright WC, Kavdia K, Pagala VR, Kim W, Wallace LM, Cho JH, Fan Y, Seth A, Twarog N, Choi JK, Obeng EA, Hatley ME, Metzger ML, Inaba H, Jeha S, Rubnitz JE, Peng J, Chen T, Shelat AA, Guy RK, Gruber TA. Kamens JL, et al. Among authors: guy rk. Nat Commun. 2023 Feb 13;14(1):809. doi: 10.1038/s41467-023-36370-x. Nat Commun. 2023. PMID: 36781850 Free PMC article.

2

A solid-phase approach to the phallotoxins: total synthesis of [Ala7]-phalloidin.

Anderson MO, Shelat AA, Guy RK. Anderson MO, et al. Among authors: guy rk. J Org Chem. 2005 Jun 10;70(12):4578-84. doi: 10.1021/jo0503153. J Org Chem. 2005. PMID: 15932292

3

A high-throughput screening method to identify small molecule inhibitors of thyroid hormone receptor coactivator binding.

Arnold LA, Estébanez-Perpiñá E, Togashi M, Shelat A, Ocasio CA, McReynolds AC, Nguyen P, Baxter JD, Fletterick RJ, Webb P, Guy RK. Arnold LA, et al. Among authors: guy rk. Sci STKE. 2006 Jun 27;2006(341):pl3. doi: 10.1126/stke.3412006pl3. Sci STKE. 2006. PMID: 16804159

4

Design of a selective chemical probe for class I PDZ domains.

Fujii N, Shelat A, Hall RA, Guy RK. Fujii N, et al. Among authors: guy rk. Bioorg Med Chem Lett. 2007 Jan 15;17(2):546-8. doi: 10.1016/j.bmcl.2006.10.027. Epub 2006 Oct 17. Bioorg Med Chem Lett. 2007. PMID: 17074480

5

The interdependence between screening methods and screening libraries.

Shelat AA, Guy RK. Shelat AA, et al. Among authors: guy rk. Curr Opin Chem Biol. 2007 Jun;11(3):244-51. doi: 10.1016/j.cbpa.2007.05.003. Epub 2007 May 23. Curr Opin Chem Biol. 2007. PMID: 17524728 Review.

6

Scaffold composition and biological relevance of screening libraries.

Shelat AA, Guy RK. Shelat AA, et al. Among authors: guy rk. Nat Chem Biol. 2007 Aug;3(8):442-6. doi: 10.1038/nchembio0807-442. Nat Chem Biol. 2007. PMID: 17637770

7

Assay Optimization and Screening of RNA-Protein Interactions by AlphaScreen.

Mills NL, Shelat AA, Guy RK. Mills NL, et al. Among authors: guy rk. J Biomol Screen. 2007 Oct;12(7):946-55. doi: 10.1177/1087057107306128. J Biomol Screen. 2007. PMID: 17942787

8

A road less traveled by: exploring a decade of Ellman chemistry.

Shelat AA, Guy RK. Shelat AA, et al. Among authors: guy rk. Bioorg Med Chem. 2009 Feb 1;17(3):1088-93. doi: 10.1016/j.bmc.2008.02.087. Epub 2008 Mar 4. Bioorg Med Chem. 2009. PMID: 18343129 Free PMC article.

9

Identification and characterization of the first small molecule inhibitor of MDMX.

Reed D, Shen Y, Shelat AA, Arnold LA, Ferreira AM, Zhu F, Mills N, Smithson DC, Regni CA, Bashford D, Cicero SA, Schulman BA, Jochemsen AG, Guy RK, Dyer MA. Reed D, et al. Among authors: guy rk. J Biol Chem. 2010 Apr 2;285(14):10786-96. doi: 10.1074/jbc.M109.056747. Epub 2010 Jan 15. J Biol Chem. 2010. PMID: 20080970 Free PMC article.

10

Optimization of a non-radioactive high-throughput assay for decarboxylase enzymes.

Smithson DC, Shelat AA, Baldwin J, Phillips MA, Guy RK. Smithson DC, et al. Among authors: guy rk. Assay Drug Dev Technol. 2010 Apr;8(2):175-85. doi: 10.1089/adt.2009.0249. Assay Drug Dev Technol. 2010. PMID: 20085486 Free PMC article.

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