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The SARS-CoV-2 Delta-Omicron Recombinant Lineage (XD) Exhibits Immune-Escape Properties Similar to the Omicron (BA.1) Variant.
Arora P, Zhang L, Rocha C, Graichen L, Nehlmeier I, Kempf A, Cossmann A, Ramos GM, Baier E, Tampe B, Moerer O, Dickel S, Winkler MS, Behrens GMN, Pöhlmann S, Hoffmann M. Arora P, et al. Among authors: rocha c. Int J Mol Sci. 2022 Nov 14;23(22):14057. doi: 10.3390/ijms232214057. Int J Mol Sci. 2022. PMID: 36430535 Free PMC article.
The spike protein of SARS-CoV-2 variant A.30 is heavily mutated and evades vaccine-induced antibodies with high efficiency.
Arora P, Rocha C, Kempf A, Nehlmeier I, Graichen L, Winkler MS, Lier M, Schulz S, Jäck HM, Cossmann A, Stankov MV, Behrens GMN, Pöhlmann S, Hoffmann M. Arora P, et al. Among authors: rocha c. Cell Mol Immunol. 2021 Dec;18(12):2673-2675. doi: 10.1038/s41423-021-00779-5. Epub 2021 Oct 25. Cell Mol Immunol. 2021. PMID: 34697413 Free PMC article. No abstract available.
The Omicron variant is highly resistant against antibody-mediated neutralization: Implications for control of the COVID-19 pandemic.
Hoffmann M, Krüger N, Schulz S, Cossmann A, Rocha C, Kempf A, Nehlmeier I, Graichen L, Moldenhauer AS, Winkler MS, Lier M, Dopfer-Jablonka A, Jäck HM, Behrens GMN, Pöhlmann S. Hoffmann M, et al. Among authors: rocha c. Cell. 2022 Feb 3;185(3):447-456.e11. doi: 10.1016/j.cell.2021.12.032. Epub 2021 Dec 24. Cell. 2022. PMID: 35026151 Free PMC article.
Alternatives to animal models and their application in the discovery of species susceptibility to SARS-CoV-2 and other respiratory infectious pathogens: A review.
Runft S, Färber I, Krüger J, Krüger N, Armando F, Rocha C, Pöhlmann S, Burigk L, Leitzen E, Ciurkiewicz M, Braun A, Schneider D, Baumgärtner L, Freisleben B, Baumgärtner W. Runft S, et al. Among authors: rocha c. Vet Pathol. 2022 Jul;59(4):565-577. doi: 10.1177/03009858211073678. Epub 2022 Feb 7. Vet Pathol. 2022. PMID: 35130766 Review.
Comparable neutralisation evasion of SARS-CoV-2 omicron subvariants BA.1, BA.2, and BA.3.
Arora P, Zhang L, Rocha C, Sidarovich A, Kempf A, Schulz S, Cossmann A, Manger B, Baier E, Tampe B, Moerer O, Dickel S, Dopfer-Jablonka A, Jäck HM, Behrens GMN, Winkler MS, Pöhlmann S, Hoffmann M. Arora P, et al. Among authors: rocha c. Lancet Infect Dis. 2022 Jun;22(6):766-767. doi: 10.1016/S1473-3099(22)00224-9. Epub 2022 Apr 12. Lancet Infect Dis. 2022. PMID: 35427493 Free PMC article. No abstract available.
SARS-CoV-2 Omicron sublineages show comparable cell entry but differential neutralization by therapeutic antibodies.
Arora P, Zhang L, Krüger N, Rocha C, Sidarovich A, Schulz S, Kempf A, Graichen L, Moldenhauer AS, Cossmann A, Dopfer-Jablonka A, Behrens GMN, Jäck HM, Pöhlmann S, Hoffmann M. Arora P, et al. Among authors: rocha c. Cell Host Microbe. 2022 Aug 10;30(8):1103-1111.e6. doi: 10.1016/j.chom.2022.04.017. Epub 2022 May 6. Cell Host Microbe. 2022. PMID: 35588741 Free PMC article.
Small-Molecule Thioesters as SARS-CoV-2 Main Protease Inhibitors: Enzyme Inhibition, Structure-Activity Relationships, Antiviral Activity, and X-ray Structure Determination.
Pillaiyar T, Flury P, Krüger N, Su H, Schäkel L, Barbosa Da Silva E, Eppler O, Kronenberger T, Nie T, Luedtke S, Rocha C, Sylvester K, Petry MRI, McKerrow JH, Poso A, Pöhlmann S, Gütschow M, O'Donoghue AJ, Xu Y, Müller CE, Laufer SA. Pillaiyar T, et al. Among authors: rocha c. J Med Chem. 2022 Jul 14;65(13):9376-9395. doi: 10.1021/acs.jmedchem.2c00636. Epub 2022 Jun 16. J Med Chem. 2022. PMID: 35709506
1,267 results