Yang RR - Search Results

1

Discovery and characterization of a novel cGAS covalent inhibitor for the treatment of inflammatory bowel disease.

Song J, Yang RR, Chang J, Liu YD, Lu CH, Chen LF, Guo H, Zhang YH, Fan ZS, Zhou JY, Zhou GZ, Zhang KK, Luo XM, Chen KX, Jiang HL, Zhang SL, Zheng MY. Song J, et al. Among authors: yang rr. Acta Pharmacol Sin. 2023 Apr;44(4):791-800. doi: 10.1038/s41401-022-01002-5. Epub 2022 Oct 13. Acta Pharmacol Sin. 2023. PMID: 36229599 Free PMC article.

2

Deep Learning Enhancing Kinome-Wide Polypharmacology Profiling: Model Construction and Experiment Validation.

Li X, Li Z, Wu X, Xiong Z, Yang T, Fu Z, Liu X, Tan X, Zhong F, Wan X, Wang D, Ding X, Yang R, Hou H, Li C, Liu H, Chen K, Jiang H, Zheng M. Li X, et al. J Med Chem. 2020 Aug 27;63(16):8723-8737. doi: 10.1021/acs.jmedchem.9b00855. Epub 2019 Aug 15. J Med Chem. 2020. PMID: 31364850

3

Discovery of novel glyceraldehyde-3-phosphate dehydrogenase inhibitor via docking-based virtual screening.

Li T, Tan X, Yang R, Miao Y, Zhang M, Xi Y, Guo R, Zheng M, Li B. Li T, et al. Bioorg Chem. 2020 Mar;96:103620. doi: 10.1016/j.bioorg.2020.103620. Epub 2020 Jan 25. Bioorg Chem. 2020. PMID: 32028064

4

Discovery of triazoloquinoxaline as novel STING agonists via structure-based virtual screening.

Hou H, Yang R, Liu X, Wu X, Zhang S, Chen K, Zheng M. Hou H, et al. Bioorg Chem. 2020 Jul;100:103958. doi: 10.1016/j.bioorg.2020.103958. Epub 2020 May 20. Bioorg Chem. 2020. PMID: 32470762

5

Cytoplasmic DNA sensing by KU complex in aged CD4⁺ T cell potentiates T cell activation and aging-related autoimmune inflammation.

Wang Y, Fu Z, Li X, Liang Y, Pei S, Hao S, Zhu Q, Yu T, Pei Y, Yuan J, Ye J, Fu J, Xu J, Hong J, Yang R, Hou H, Huang X, Peng C, Zheng M, Xiao Y. Wang Y, et al. Immunity. 2021 Apr 13;54(4):632-647.e9. doi: 10.1016/j.immuni.2021.02.003. Epub 2021 Mar 4. Immunity. 2021. PMID: 33667382 Free article.

6

Drug target inference by mining transcriptional data using a novel graph convolutional network framework.

Zhong F, Wu X, Yang R, Li X, Wang D, Fu Z, Liu X, Wan X, Yang T, Fan Z, Zhang Y, Luo X, Chen K, Zhang S, Jiang H, Zheng M. Zhong F, et al. Protein Cell. 2022 Apr;13(4):281-301. doi: 10.1007/s13238-021-00885-0. Epub 2021 Oct 22. Protein Cell. 2022. PMID: 34677780 Free PMC article.

7

Discovery of Pyrazolo[3,4-d]pyridazinone Derivatives as Selective DDR1 Inhibitors via Deep Learning Based Design, Synthesis, and Biological Evaluation.

Tan X, Li C, Yang R, Zhao S, Li F, Li X, Chen L, Wan X, Liu X, Yang T, Tong X, Xu T, Cui R, Jiang H, Zhang S, Liu H, Zheng M. Tan X, et al. J Med Chem. 2022 Jan 13;65(1):103-119. doi: 10.1021/acs.jmedchem.1c01205. Epub 2021 Nov 25. J Med Chem. 2022. PMID: 34821145

8

Discovery of ARF1-targeting inhibitor demethylzeylasteral as a potential agent against breast cancer.

Chang J, Yang R, Chen L, Fan Z, Zhou J, Guo H, Zhang Y, Liu Y, Zhou G, Zhang K, Chen K, Jiang H, Zheng M, Zhang S. Chang J, et al. Acta Pharm Sin B. 2022 May;12(5):2619-2622. doi: 10.1016/j.apsb.2022.02.011. Epub 2022 Feb 16. Acta Pharm Sin B. 2022. PMID: 35646528 Free PMC article.

9

Discovery and identification of a novel small molecule BCL-2 inhibitor that binds to the BH4 domain.

Zhou JY, Yang RR, Chang J, Song J, Fan ZS, Zhang YH, Lu CH, Jiang HL, Zheng MY, Zhang SL. Zhou JY, et al. Among authors: yang rr. Acta Pharmacol Sin. 2023 Feb;44(2):475-485. doi: 10.1038/s41401-022-00936-0. Epub 2022 Aug 2. Acta Pharmacol Sin. 2023. PMID: 35918411 Free PMC article.

10

Targeting UHRF1-SAP30-MXD4 axis for leukemia initiating cell eradication in myeloid leukemia.

Hu CL, Chen BY, Li Z, Yang T, Xu CH, Yang R, Yu PC, Zhao J, Liu T, Liu N, Shan B, Zhang Q, Song J, Fei MY, Zong LJ, Zhang JY, Wu JC, Chen SB, Wang Y, Chang B, Hou D, Liu P, Jiang Y, Li X, Chen X, Deng CH, Ren YY, Wang R, Jin J, Xue K, Zhang Y, Du M, Shi J, Wu LY, Chang CK, Shen S, Chen Z, Chen SJ, Liu X, Sun XJ, Zheng M, Wang L. Hu CL, et al. Cell Res. 2022 Dec;32(12):1105-1123. doi: 10.1038/s41422-022-00735-6. Epub 2022 Oct 27. Cell Res. 2022. PMID: 36302855 Free PMC article.

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