Chen LF - Search Results

1

Discovery and characterization of a novel cGAS covalent inhibitor for the treatment of inflammatory bowel disease.

Song J, Yang RR, Chang J, Liu YD, Lu CH, Chen LF, Guo H, Zhang YH, Fan ZS, Zhou JY, Zhou GZ, Zhang KK, Luo XM, Chen KX, Jiang HL, Zhang SL, Zheng MY. Song J, et al. Among authors: chen kx, chen lf. Acta Pharmacol Sin. 2023 Apr;44(4):791-800. doi: 10.1038/s41401-022-01002-5. Epub 2022 Oct 13. Acta Pharmacol Sin. 2023. PMID: 36229599 Free PMC article.

2

TransformerCPI: improving compound-protein interaction prediction by sequence-based deep learning with self-attention mechanism and label reversal experiments.

Chen L, Tan X, Wang D, Zhong F, Liu X, Yang T, Luo X, Chen K, Jiang H, Zheng M. Chen L, et al. Bioinformatics. 2020 Aug 15;36(16):4406-4414. doi: 10.1093/bioinformatics/btaa524. Bioinformatics. 2020. PMID: 32428219

3

Drug repurposing against breast cancer by integrating drug-exposure expression profiles and drug-drug links based on graph neural network.

Cui C, Ding X, Wang D, Chen L, Xiao F, Xu T, Zheng M, Luo X, Jiang H, Chen K. Cui C, et al. Bioinformatics. 2021 Sep 29;37(18):2930-2937. doi: 10.1093/bioinformatics/btab191. Bioinformatics. 2021. PMID: 33739367 Free PMC article.

4

A hybrid framework for improving uncertainty quantification in deep learning-based QSAR regression modeling.

Wang D, Yu J, Chen L, Li X, Jiang H, Chen K, Zheng M, Luo X. Wang D, et al. J Cheminform. 2021 Sep 20;13(1):69. doi: 10.1186/s13321-021-00551-x. J Cheminform. 2021. PMID: 34544485 Free PMC article.

5

Discovery of Pyrazolo[3,4-d]pyridazinone Derivatives as Selective DDR1 Inhibitors via Deep Learning Based Design, Synthesis, and Biological Evaluation.

Tan X, Li C, Yang R, Zhao S, Li F, Li X, Chen L, Wan X, Liu X, Yang T, Tong X, Xu T, Cui R, Jiang H, Zhang S, Liu H, Zheng M. Tan X, et al. J Med Chem. 2022 Jan 13;65(1):103-119. doi: 10.1021/acs.jmedchem.1c01205. Epub 2021 Nov 25. J Med Chem. 2022. PMID: 34821145

6

Graph neural network approaches for drug-target interactions.

Zhang Z, Chen L, Zhong F, Wang D, Jiang J, Zhang S, Jiang H, Zheng M, Li X. Zhang Z, et al. Curr Opin Struct Biol. 2022 Apr;73:102327. doi: 10.1016/j.sbi.2021.102327. Epub 2022 Jan 21. Curr Opin Struct Biol. 2022. PMID: 35074533 Review.

7

Discovery of ARF1-targeting inhibitor demethylzeylasteral as a potential agent against breast cancer.

Chang J, Yang R, Chen L, Fan Z, Zhou J, Guo H, Zhang Y, Liu Y, Zhou G, Zhang K, Chen K, Jiang H, Zheng M, Zhang S. Chang J, et al. Acta Pharm Sin B. 2022 May;12(5):2619-2622. doi: 10.1016/j.apsb.2022.02.011. Epub 2022 Feb 16. Acta Pharm Sin B. 2022. PMID: 35646528 Free PMC article.

8

Goliath induces inflammation in obese mice by linking fatty acid β-oxidation to glycolysis.

Hao S, Zhang S, Ye J, Chen L, Wang Y, Pei S, Zhu Q, Xu J, Tao Y, Zhou N, Yin H, Duan CW, Mao C, Zheng M, Xiao Y. Hao S, et al. EMBO Rep. 2023 Apr 5;24(4):e56932. doi: 10.15252/embr.202356932. Epub 2023 Mar 2. EMBO Rep. 2023. PMID: 36862324 Free PMC article.

9

Sequence-based drug design as a concept in computational drug design.

Chen L, Fan Z, Chang J, Yang R, Hou H, Guo H, Zhang Y, Yang T, Zhou C, Sui Q, Chen Z, Zheng C, Hao X, Zhang K, Cui R, Zhang Z, Ma H, Ding Y, Zhang N, Lu X, Luo X, Jiang H, Zhang S, Zheng M. Chen L, et al. Nat Commun. 2023 Jul 14;14(1):4217. doi: 10.1038/s41467-023-39856-w. Nat Commun. 2023. PMID: 37452028 Free PMC article.

10

Learning protein fitness landscapes with deep mutational scanning data from multiple sources.

Chen L, Zhang Z, Li Z, Li R, Huo R, Chen L, Wang D, Luo X, Chen K, Liao C, Zheng M. Chen L, et al. Cell Syst. 2023 Aug 16;14(8):706-721.e5. doi: 10.1016/j.cels.2023.07.003. Cell Syst. 2023. PMID: 37591206

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