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An engineered 5-helix bundle derived from SARS-CoV-2 S2 pre-binds sarbecoviral spike at both serological- and endosomal-pH to inhibit virus entry.
Lin X, Guo L, Lin S, Chen Z, Yang F, Yang J, Wang L, Wen A, Duan Y, Zhang X, Dai Y, Yin K, Yuan X, Yu C, He B, Cao Y, Dong H, Li J, Zhao Q, Lu G. Lin X, et al. Among authors: yu c. Emerg Microbes Infect. 2022 Dec;11(1):1920-1935. doi: 10.1080/22221751.2022.2095308. Emerg Microbes Infect. 2022. PMID: 35757908 Free PMC article.
Characterization of SARS-CoV-2 Omicron spike RBD reveals significantly decreased stability, severe evasion of neutralizing-antibody recognition but unaffected engagement by decoy ACE2 modified for enhanced RBD binding.
Lin S, Chen Z, Zhang X, Wen A, Yuan X, Yu C, Yang J, He B, Cao Y, Lu G. Lin S, et al. Among authors: yu c. Signal Transduct Target Ther. 2022 Feb 21;7(1):56. doi: 10.1038/s41392-022-00914-2. Signal Transduct Target Ther. 2022. PMID: 35190526 Free PMC article. No abstract available.
Structural and functional basis of low-affinity SAM/SAH-binding in the conserved MTase of the multi-segmented Alongshan virus distantly related to canonical unsegmented flaviviruses.
Chen H, Lin S, Yang F, Chen Z, Guo L, Yang J, Lin X, Wang L, Duan Y, Wen A, Zhang X, Dai Y, Yin K, Yuan X, Yu C, He Y, He B, Cao Y, Dong H, Li J, Zhao Q, Liu Q, Lu G. Chen H, et al. Among authors: yu c. PLoS Pathog. 2023 Oct 13;19(10):e1011694. doi: 10.1371/journal.ppat.1011694. eCollection 2023 Oct. PLoS Pathog. 2023. PMID: 37831643 Free PMC article.
Development of a bispecific nanobody conjugate broadly neutralizes diverse SARS-CoV-2 variants and structural basis for its broad neutralization.
Yang J, Lin S, Chen Z, Yang F, Guo L, Wang L, Duan Y, Zhang X, Dai Y, Yin K, Yu C, Yuan X, Sun H, He B, Cao Y, Ye H, Dong H, Liu X, Chen B, Li J, Zhao Q, Lu G. Yang J, et al. Among authors: yu c. PLoS Pathog. 2023 Nov 30;19(11):e1011804. doi: 10.1371/journal.ppat.1011804. eCollection 2023 Nov. PLoS Pathog. 2023. PMID: 38033141 Free PMC article.
Cross-ancestry genome-wide association studies of brain imaging phenotypes.
Fu J, Zhang Q, Wang J, Wang M, Zhang B, Zhu W, Qiu S, Geng Z, Cui G, Yu Y, Liao W, Zhang H, Gao B, Xu X, Han T, Yao Z, Qin W, Liu F, Liang M, Wang S, Xu Q, Xu J, Zhang P, Li W, Shi D, Wang C, Lui S, Yan Z, Chen F, Zhang J, Li J, Shen W, Miao Y, Wang D, Xian J, Gao JH, Zhang X, Xu K, Zuo XN, Zhang L, Ye Z, Cheng J, Li MJ, Yu C; CHIMGEN Consortium. Fu J, et al. Among authors: yu c. Nat Genet. 2024 May 29. doi: 10.1038/s41588-024-01766-y. Online ahead of print. Nat Genet. 2024. PMID: 38811844
Correction: Linking bacterial enterotoxins and alpha defensin 5 expansion in the Crohn's colitis: A new insight into the etiopathogenetic and differentiation triggers driving colonic inflammatory bowel disease.
Rana T, Korolkova OY, Rachakonda G, Williams AD, Hawkins AT, James SD, Sakwe AM, Nian H, Wang L, Yu C, Goodwin JS, Izban MG, Offodile RS, Washington MK, Ballard BR, Smoot DT, Shi XZ, Forbes DS, Shanker A, M'Koma AE. Rana T, et al. Among authors: yu c. PLoS One. 2024 May 29;19(5):e0304732. doi: 10.1371/journal.pone.0304732. eCollection 2024. PLoS One. 2024. PMID: 38809824 Free PMC article.
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