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The three-tails approach as a new strategy to improve selectivity of action of sulphonamide inhibitors against tumour-associated carbonic anhydrase IX and XII.
Bonardi A, Bua S, Combs J, Lomelino C, Andring J, Osman SM, Toti A, Di Cesare Mannelli L, Gratteri P, Ghelardini C, McKenna R, Nocentini A, Supuran CT. Bonardi A, et al. Among authors: ghelardini c. J Enzyme Inhib Med Chem. 2022 Dec;37(1):930-939. doi: 10.1080/14756366.2022.2053526. J Enzyme Inhib Med Chem. 2022. PMID: 35306936 Free PMC article.
Menthol: a natural analgesic compound.
Galeotti N, Di Cesare Mannelli L, Mazzanti G, Bartolini A, Ghelardini C. Galeotti N, et al. Among authors: ghelardini c. Neurosci Lett. 2002 Apr 12;322(3):145-8. doi: 10.1016/s0304-3940(01)02527-7. Neurosci Lett. 2002. PMID: 11897159
Structural investigation of the 7-chloro-3-hydroxy-1H-quinazoline-2,4-dione scaffold to obtain AMPA and kainate receptor selective antagonists. Synthesis, pharmacological, and molecular modeling studies.
Colotta V, Catarzi D, Varano F, Lenzi O, Filacchioni G, Costagli C, Galli A, Ghelardini C, Galeotti N, Gratteri P, Sgrignani J, Deflorian F, Moro S. Colotta V, et al. Among authors: ghelardini c. J Med Chem. 2006 Oct 5;49(20):6015-26. doi: 10.1021/jm0604880. J Med Chem. 2006. PMID: 17004715
Synthesis and structure-activity relationship studies in translocator protein ligands based on a pyrazolo[3,4-b]quinoline scaffold.
Cappelli A, Bini G, Valenti S, Giuliani G, Paolino M, Anzini M, Vomero S, Giorgi G, Giordani A, Stasi LP, Makovec F, Ghelardini C, Di Cesare Mannelli L, Concas A, Porcu P, Biggio G. Cappelli A, et al. Among authors: ghelardini c. J Med Chem. 2011 Oct 27;54(20):7165-75. doi: 10.1021/jm200770f. Epub 2011 Sep 26. J Med Chem. 2011. PMID: 21916402
487 results