Abstract
A series of cis and trans 3,7-diazabicyclo[4.3.0]nonan-8-ones has been synthesized and tested for their ability to revert scopolamine-induced amnesia in the mouse passive-avoidance test. The racemates of the most potent compounds 4 and 7 were separated and tested, but no enantioselectivity was found for the nootropic activity. Compounds 4 and 7 and their enantiomers displayed interesting antihyperalgesic activity in two models of neuropathic pain (streptozotocin-induced and oxalilplatin-induced neuropathy) in comparison with pregabalin.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amnesia / chemically induced
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Amnesia / drug therapy
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Analgesics / chemical synthesis*
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Analgesics / chemistry
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Analgesics / pharmacology*
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Analgesics / therapeutic use
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Animals
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Behavior, Animal / drug effects
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Drug Design
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Ketones / chemical synthesis*
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Ketones / chemistry
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Ketones / pharmacology*
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Ketones / therapeutic use
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Mice
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Nootropic Agents / chemical synthesis*
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Nootropic Agents / chemistry
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Nootropic Agents / pharmacology*
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Nootropic Agents / therapeutic use
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Scopolamine / pharmacology
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Stereoisomerism
Substances
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Analgesics
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Ketones
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Nootropic Agents
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Scopolamine