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M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome.
Nat Chem Biol. 2022 May;18(5):565-574. doi: 10.1038/s41589-021-00964-7. Epub 2022 Feb 14.
Nat Chem Biol. 2022.
PMID: 35165443
Free PMC article.
Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes.
Robert Hollingsworth L, David L, Li Y, Griswold AR, Ruan J, Sharif H, Fontana P, Orth-He EL, Fu TM, Bachovchin DA, Wu H.
Robert Hollingsworth L, et al. Among authors: orth he el.
Nat Commun. 2021 Jan 8;12(1):189. doi: 10.1038/s41467-020-20320-y.
Nat Commun. 2021.
PMID: 33420033
Free PMC article.
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A ubiquitin-independent proteasome pathway controls activation of the CARD8 inflammasome.
Hsiao JC, Neugroschl AR, Chui AJ, Taabazuing CY, Griswold AR, Wang Q, Huang HC, Orth-He EL, Ball DP, Hiotis G, Bachovchin DA.
Hsiao JC, et al. Among authors: orth he el.
J Biol Chem. 2022 Jul;298(7):102032. doi: 10.1016/j.jbc.2022.102032. Epub 2022 May 14.
J Biol Chem. 2022.
PMID: 35580636
Free PMC article.
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Optimized M24B Aminopeptidase Inhibitors for CARD8 Inflammasome Activation.
Chen Q, Wang A, Covelli DJ, Bhattacharjee A, Wang Q, Orth-He EL, Rao SD, Huang HC, Ball DP, Hsiao JC, Bachovchin DA.
Chen Q, et al. Among authors: orth he el.
J Med Chem. 2023 Feb 23;66(4):2589-2607. doi: 10.1021/acs.jmedchem.2c01535. Epub 2023 Feb 1.
J Med Chem. 2023.
PMID: 36724486
Free PMC article.
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Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation.
Orth-He EL, Huang HC, Rao SD, Wang Q, Chen Q, O'Mara CM, Chui AJ, Saoi M, Griswold AR, Bhattacharjee A, Ball DP, Cross JR, Bachovchin DA.
Orth-He EL, et al.
Cell Rep. 2023 Jan 31;42(1):111965. doi: 10.1016/j.celrep.2022.111965. Epub 2023 Jan 16.
Cell Rep. 2023.
PMID: 36649711
Free PMC article.
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The NLRP1 and CARD8 inflammasomes detect reductive stress.
Wang Q, Hsiao JC, Yardeny N, Huang HC, O'Mara CM, Orth-He EL, Ball DP, Zhang Z, Bachovchin DA.
Wang Q, et al. Among authors: orth he el.
Cell Rep. 2023 Jan 31;42(1):111966. doi: 10.1016/j.celrep.2022.111966. Epub 2023 Jan 16.
Cell Rep. 2023.
PMID: 36649710
Free PMC article.
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