Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

Search Results

6 results

Filters applied: . Clear all
Results are displayed in a computed author sort order. The Results By Year timeline is not available.
Page 1
M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome.
Rao SD, Chen Q, Wang Q, Orth-He EL, Saoi M, Griswold AR, Bhattacharjee A, Ball DP, Huang HC, Chui AJ, Covelli DJ, You S, Cross JR, Bachovchin DA. Rao SD, et al. Among authors: orth he el. Nat Chem Biol. 2022 May;18(5):565-574. doi: 10.1038/s41589-021-00964-7. Epub 2022 Feb 14. Nat Chem Biol. 2022. PMID: 35165443 Free PMC article.
Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes.
Robert Hollingsworth L, David L, Li Y, Griswold AR, Ruan J, Sharif H, Fontana P, Orth-He EL, Fu TM, Bachovchin DA, Wu H. Robert Hollingsworth L, et al. Among authors: orth he el. Nat Commun. 2021 Jan 8;12(1):189. doi: 10.1038/s41467-020-20320-y. Nat Commun. 2021. PMID: 33420033 Free PMC article.
Optimized M24B Aminopeptidase Inhibitors for CARD8 Inflammasome Activation.
Chen Q, Wang A, Covelli DJ, Bhattacharjee A, Wang Q, Orth-He EL, Rao SD, Huang HC, Ball DP, Hsiao JC, Bachovchin DA. Chen Q, et al. Among authors: orth he el. J Med Chem. 2023 Feb 23;66(4):2589-2607. doi: 10.1021/acs.jmedchem.2c01535. Epub 2023 Feb 1. J Med Chem. 2023. PMID: 36724486 Free PMC article.
Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation.
Orth-He EL, Huang HC, Rao SD, Wang Q, Chen Q, O'Mara CM, Chui AJ, Saoi M, Griswold AR, Bhattacharjee A, Ball DP, Cross JR, Bachovchin DA. Orth-He EL, et al. Cell Rep. 2023 Jan 31;42(1):111965. doi: 10.1016/j.celrep.2022.111965. Epub 2023 Jan 16. Cell Rep. 2023. PMID: 36649711 Free PMC article.
The NLRP1 and CARD8 inflammasomes detect reductive stress.
Wang Q, Hsiao JC, Yardeny N, Huang HC, O'Mara CM, Orth-He EL, Ball DP, Zhang Z, Bachovchin DA. Wang Q, et al. Among authors: orth he el. Cell Rep. 2023 Jan 31;42(1):111966. doi: 10.1016/j.celrep.2022.111966. Epub 2023 Jan 16. Cell Rep. 2023. PMID: 36649710 Free PMC article.