Sharma SK - Search Results

1

Studies on the Importance of the 7α-, and 12α- hydroxyl groups of N-Aryl-3α,7α,12α-trihydroxy-5β-cholan-24-amides on their Antigermination Activity Against a Hypervirulent Strain of Clostridioides (Clostridium) difficile.

Sharma SK, Yip C, Simon MP, Phan J, Abel-Santos E, Firestine SM. Sharma SK, et al. Bioorg Med Chem. 2021 Dec 15;52:116503. doi: 10.1016/j.bmc.2021.116503. Epub 2021 Nov 10. Bioorg Med Chem. 2021. PMID: 34837818 Free PMC article.

2

(Bis)urea and (bis)thiourea inhibitors of lysine-specific demethylase 1 as epigenetic modulators.

Sharma SK, Wu Y, Steinbergs N, Crowley ML, Hanson AS, Casero RA, Woster PM. Sharma SK, et al. J Med Chem. 2010 Jul 22;53(14):5197-212. doi: 10.1021/jm100217a. J Med Chem. 2010. PMID: 20568780 Free PMC article.

3

Ligand modifications to reduce the relative resistance of multi-drug resistant HIV-1 protease.

Dewdney TG, Wang Y, Liu Z, Sharma SK, Reiter SJ, Brunzelle JS, Kovari IA, Woster PM, Kovari LC. Dewdney TG, et al. Among authors: sharma sk. Bioorg Med Chem. 2013 Dec 1;21(23):7430-4. doi: 10.1016/j.bmc.2013.09.045. Epub 2013 Sep 27. Bioorg Med Chem. 2013. PMID: 24128815

4

Structure-activity study for (bis)ureidopropyl- and (bis)thioureidopropyldiamine LSD1 inhibitors with 3-5-3 and 3-6-3 carbon backbone architectures.

Nowotarski SL, Pachaiyappan B, Holshouser SL, Kutz CJ, Li Y, Huang Y, Sharma SK, Casero RA Jr, Woster PM. Nowotarski SL, et al. Among authors: sharma sk. Bioorg Med Chem. 2015 Apr 1;23(7):1601-12. doi: 10.1016/j.bmc.2015.01.049. Epub 2015 Feb 7. Bioorg Med Chem. 2015. PMID: 25725609 Free PMC article.

5

Corrigendum to "Structure-activity study for (bis)ureidopropyl- and (bis)thioureidopropyldiamine LSD1 inhibitors with 3-5-3 and 3-6-3 carbon backbone architectures" [Bioorg. Med. Chem. 23 (2015) 1601-1612].

Nowotarski SL, Pachaiyappan B, Holshouser SL, Kutz CJ, Li Y, Huang Y, Sharma SK, Casero RA Jr, Woster PM. Nowotarski SL, et al. Among authors: sharma sk. Bioorg Med Chem. 2018 Jul 23;26(12):3728-3729. doi: 10.1016/j.bmc.2018.05.032. Epub 2018 May 30. Bioorg Med Chem. 2018. PMID: 29859749 No abstract available.

6

The Design, Synthesis, and Characterizations of Spore Germination Inhibitors Effective against an Epidemic Strain of Clostridium difficile.

Sharma SK, Yip C, Esposito EX, Sharma PV, Simon MP, Abel-Santos E, Firestine SM. Sharma SK, et al. Among authors: sharma pv. J Med Chem. 2018 Aug 9;61(15):6759-6778. doi: 10.1021/acs.jmedchem.8b00632. Epub 2018 Jul 30. J Med Chem. 2018. PMID: 30004695 Free PMC article.

7

Physicochemical and In Vitro Evaluation of Drug Delivery of an Antibacterial Synthetic Benzophenone in Biodegradable PLGA Nanoparticles.

Costabile G, Gasteyer KI, Nadithe V, Van Denburgh K, Lin Q, Sharma S, Reineke JJ, Firestine SM, Merkel OM. Costabile G, et al. AAPS PharmSciTech. 2018 Nov;19(8):3561-3570. doi: 10.1208/s12249-018-1187-9. Epub 2018 Sep 25. AAPS PharmSciTech. 2018. PMID: 30255472

8

An Aniline-Substituted Bile Salt Analog Protects both Mice and Hamsters from Multiple Clostridioides difficile Strains.

Phan JR, Do DM, Truong MC, Ngo C, Phan JH, Sharma SK, Schilke A, Mefferd CC, Villarama JV, Lai D, Consul A, Hedlund BP, Firestine SM, Abel-Santos E. Phan JR, et al. Among authors: sharma sk. Antimicrob Agents Chemother. 2022 Jan 18;66(1):e0143521. doi: 10.1128/AAC.01435-21. Epub 2021 Nov 15. Antimicrob Agents Chemother. 2022. PMID: 34780262 Free PMC article.

9

A Fluorescence-Based Assay for N⁵ -Carboxyaminoimidazole Ribonucleotide Mutase.

Sharma MF, Sharma SK, Streeter CC, Firestine SM. Sharma MF, et al. Among authors: sharma sk. Chembiochem. 2023 Sep 15;24(18):e202300347. doi: 10.1002/cbic.202300347. Epub 2023 Aug 16. Chembiochem. 2023. PMID: 37474455

10

The design, synthesis, and inhibition of Clostridioides difficile spore germination by acyclic and bicyclic tertiary amide analogs of cholate.

Sharma SK, Schilke AR, Phan JR, Yip C, Sharma PV, Abel-Santos E, Firestine SM. Sharma SK, et al. Among authors: sharma pv. Eur J Med Chem. 2023 Dec 5;261:115788. doi: 10.1016/j.ejmech.2023.115788. Epub 2023 Sep 4. Eur J Med Chem. 2023. PMID: 37703709

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