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Cas9-specific immune responses compromise local and systemic AAV CRISPR therapy in multiple dystrophic canine models.
Hakim CH, Kumar SRP, Pérez-López DO, Wasala NB, Zhang D, Yue Y, Teixeira J, Pan X, Zhang K, Million ED, Nelson CE, Metzger S, Han J, Louderman JA, Schmidt F, Feng F, Grimm D, Smith BF, Yao G, Yang NN, Gersbach CA, Chen SJ, Herzog RW, Duan D. Hakim CH, et al. Among authors: gersbach ca. Nat Commun. 2021 Nov 24;12(1):6769. doi: 10.1038/s41467-021-26830-7. Nat Commun. 2021. PMID: 34819506 Free PMC article.
RNA-guided gene activation by CRISPR-Cas9-based transcription factors.
Perez-Pinera P, Kocak DD, Vockley CM, Adler AF, Kabadi AM, Polstein LR, Thakore PI, Glass KA, Ousterout DG, Leong KW, Guilak F, Crawford GE, Reddy TE, Gersbach CA. Perez-Pinera P, et al. Among authors: gersbach ca. Nat Methods. 2013 Oct;10(10):973-6. doi: 10.1038/nmeth.2600. Epub 2013 Jul 25. Nat Methods. 2013. PMID: 23892895 Free PMC article.
Cas9 loosens its grip on off-target sites.
Nelson CE, Gersbach CA. Nelson CE, et al. Among authors: gersbach ca. Nat Biotechnol. 2016 Mar;34(3):298-9. doi: 10.1038/nbt.3501. Nat Biotechnol. 2016. PMID: 26963555 No abstract available.
Engineering Delivery Vehicles for Genome Editing.
Nelson CE, Gersbach CA. Nelson CE, et al. Among authors: gersbach ca. Annu Rev Chem Biomol Eng. 2016 Jun 7;7:637-62. doi: 10.1146/annurev-chembioeng-080615-034711. Epub 2016 Apr 21. Annu Rev Chem Biomol Eng. 2016. PMID: 27146557 Review.
133 results