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Synthesis of heteroaromatic analogues of (2-aryl-1-cyclopentenyl-1-alkylidene)-(arylmethyloxy)amine COX-2 inhibitors: effects on the inhibitory activity of the replacement of the cyclopentene central core with pyrazole, thiophene or isoxazole ring.
Balsamo A, Coletta I, Guglielmotti A, Landolfi C, Mancini F, Martinelli A, Milanese C, Minutolo F, Nencetti S, Orlandini E, Pinza M, Rapposelli S, Rossello A. Balsamo A, et al. Among authors: orlandini e. Eur J Med Chem. 2003 Feb;38(2):157-68. doi: 10.1016/s0223-5234(02)01448-4. Eur J Med Chem. 2003. PMID: 12620660
Synthesis and 5-HT2A, 5-HT1A and alpha1-binding affinities of 2-[2-Hydroxy-3-(pyridin-3-yl-methyl)amino]-, 2-[2-hydroxy-3-(2-pyridin-2-yl-ethyl)amino]- and 2-[2-hydroxy-3-(4-N-methyl-piperazin-1-yl)-amino]propoxybenzaldehyde-O-(substituted) benzyl oximes.
Orlandini E, Rapposelli S, Nencetti S, Giannaccini G, Betti L, Balsamo A. Orlandini E, et al. Arch Pharm (Weinheim). 2007 Mar;340(3):135-9. doi: 10.1002/ardp.200600123. Arch Pharm (Weinheim). 2007. PMID: 17335104
242 results