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Clinical trial in a dish using iPSCs shows lovastatin improves endothelial dysfunction and cellular cross-talk in LMNA cardiomyopathy.
Sayed N, Liu C, Ameen M, Himmati F, Zhang JZ, Khanamiri S, Moonen JR, Wnorowski A, Cheng L, Rhee JW, Gaddam S, Wang KC, Sallam K, Boyd JH, Woo YJ, Rabinovitch M, Wu JC. Sayed N, et al. Among authors: sallam k. Sci Transl Med. 2020 Jul 29;12(554):eaax9276. doi: 10.1126/scitranslmed.aax9276. Sci Transl Med. 2020. PMID: 32727917 Free PMC article.
Modeling Effects of Immunosuppressive Drugs on Human Hearts Using Induced Pluripotent Stem Cell-Derived Cardiac Organoids and Single-Cell RNA Sequencing.
Sallam K, Thomas D, Gaddam S, Lopez N, Beck A, Beach L, Rogers AJ, Zhang H, Chen IY, Ameen M, Hiesinger W, Teuteberg JJ, Rhee JW, Wang KC, Sayed N, Wu JC. Sallam K, et al. Circulation. 2022 Apr 26;145(17):1367-1369. doi: 10.1161/CIRCULATIONAHA.121.054317. Epub 2022 Apr 25. Circulation. 2022. PMID: 35467958 Free PMC article. No abstract available.
Modeling inherited cardiac disorders.
Sallam K, Kodo K, Wu JC. Sallam K, et al. Circ J. 2014;78(4):784-94. doi: 10.1253/circj.cj-14-0182. Epub 2014 Mar 17. Circ J. 2014. PMID: 24632794 Free PMC article. Review.
Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity.
Liang P, Lan F, Lee AS, Gong T, Sanchez-Freire V, Wang Y, Diecke S, Sallam K, Knowles JW, Wang PJ, Nguyen PK, Bers DM, Robbins RC, Wu JC. Liang P, et al. Among authors: sallam k. Circulation. 2013 Apr 23;127(16):1677-91. doi: 10.1161/CIRCULATIONAHA.113.001883. Epub 2013 Mar 21. Circulation. 2013. PMID: 23519760 Free PMC article.
107 results