Modeling Effects of Immunosuppressive Drugs on Human Hearts Using Induced Pluripotent Stem Cell-Derived Cardiac Organoids and Single-Cell RNA Sequencing

Circulation. 2022 Apr 26;145(17):1367-1369. doi: 10.1161/CIRCULATIONAHA.121.054317. Epub 2022 Apr 25.

Karim Sallam^{1

2}, Dilip Thomas¹, Sadhana Gaddam³, Nicole Lopez¹, Aimee Beck¹, Leila Beach², Albert J Rogers^{1

2}, Hao Zhang¹, Ian Y Chen^{1

2}, Mohamed Ameen¹, William Hiesinger⁴, Jeffrey J Teuteberg², June-Wha Rhee^{1

2}, Kevin C Wang³, Nazish Sayed^{1

5}, Joseph C Wu^{1

2}

¹ Stanford Cardiovascular Institute (K.S., D.T., N.L., A.B., A.J.R., H.Z., I.Y.C., M.A., J.-W.R., N.S., J.C.W.), Stanford University School of Medicine, CA.
² Division of Cardiovascular Medicine, Department of Medicine (K.S., L.B., A.J.R., I.Y.C., J.J.T., J.-W.R., J.C.W.), Stanford University School of Medicine, CA.
³ Department of Dermatology (S.G., K.C.W.), Stanford University School of Medicine, CA.
⁴ Department of Cardiothoracic Surgery (W.H.), Stanford University School of Medicine, CA.
⁵ Division of Vascular Surgery, Department of Surgery (N.S.), Stanford University School of Medicine, CA.

No abstract available

Keywords: fibroblasts; heart transplantation; immunosuppression therapy; ventricular remodeling.

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