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Comprehensive structure-activity-relationship of azaindoles as highly potent FLT3 inhibitors.
Grimm SH, Gagestein B, Keijzer JF, Liu N, Wijdeven RH, Lenselink EB, Tuin AW, van den Nieuwendijk AMCH, van Westen GJP, van Boeckel CAA, Overkleeft HS, Neefjes J, van der Stelt M. Grimm SH, et al. Among authors: van der stelt m, van boeckel caa, van westen gjp, van den nieuwendijk amch. Bioorg Med Chem. 2019 Mar 1;27(5):692-699. doi: 10.1016/j.bmc.2019.01.006. Epub 2019 Jan 14. Bioorg Med Chem. 2019. PMID: 30661740 Free article.
Structure Kinetics Relationships and Molecular Dynamics Show Crucial Role for Heterocycle Leaving Group in Irreversible Diacylglycerol Lipase Inhibitors.
Janssen APA, van Hengst JMA, Béquignon OJM, Deng H, van Westen GJP, van der Stelt M. Janssen APA, et al. Among authors: van der stelt m, van westen gjp, van hengst jma. J Med Chem. 2019 Sep 12;62(17):7910-7922. doi: 10.1021/acs.jmedchem.9b00686. Epub 2019 Aug 30. J Med Chem. 2019. PMID: 31437392 Free PMC article.
Successive Statistical and Structure-Based Modeling to Identify Chemically Novel Kinase Inhibitors.
Burggraaff L, Lenselink EB, Jespers W, van Engelen J, Bongers BJ, González MG, Liu R, Hoos HH, van Vlijmen HWT, IJzerman AP, van Westen GJP. Burggraaff L, et al. Among authors: van westen gjp, van vlijmen hwt, van engelen j. J Chem Inf Model. 2020 Sep 28;60(9):4283-4295. doi: 10.1021/acs.jcim.9b01204. Epub 2020 May 12. J Chem Inf Model. 2020. PMID: 32343143 Free PMC article.
Characterization of cancer-related somatic mutations in the adenosine A2B receptor.
Wang X, Jespers W, Bongers BJ, Habben Jansen MCC, Stangenberger CM, Dilweg MA, Gutiérrez-de-Terán H, IJzerman AP, Heitman LH, van Westen GJP. Wang X, et al. Among authors: van westen gjp. Eur J Pharmacol. 2020 Aug 5;880:173126. doi: 10.1016/j.ejphar.2020.173126. Epub 2020 Apr 26. Eur J Pharmacol. 2020. PMID: 32348778 Free article.
Structure-Activity Relationship Studies of α-Ketoamides as Inhibitors of the Phospholipase A and Acyltransferase Enzyme Family.
Zhou J, Mock ED, Al Ayed K, Di X, Kantae V, Burggraaff L, Stevens AF, Martella A, Mohr F, Jiang M, van der Wel T, Wendel TJ, Ofman TP, Tran Y, de Koster N, van Westen GJP, Hankemeier T, van der Stelt M. Zhou J, et al. Among authors: van der stelt m, van der wel t, van westen gjp. J Med Chem. 2020 Sep 10;63(17):9340-9359. doi: 10.1021/acs.jmedchem.0c00522. Epub 2020 Aug 13. J Med Chem. 2020. PMID: 32787138 Free PMC article.
Crystal Structure and Subsequent Ligand Design of a Nonriboside Partial Agonist Bound to the Adenosine A2A Receptor.
Amelia T, van Veldhoven JPD, Falsini M, Liu R, Heitman LH, van Westen GJP, Segala E, Verdon G, Cheng RKY, Cooke RM, van der Es D, IJzerman AP. Amelia T, et al. Among authors: van westen gjp, van der es d, van veldhoven jpd. J Med Chem. 2021 Apr 8;64(7):3827-3842. doi: 10.1021/acs.jmedchem.0c01856. Epub 2021 Mar 25. J Med Chem. 2021. PMID: 33764785 Free PMC article.
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