Brodsky JL - Search Results

1

Synthesis and evaluation of bifunctional PTP4A3 phosphatase inhibitors activating the ER stress pathway.

Rastelli EJ, Sannino S, Hart DJ, Sharlow ER, Lazo JS, Brodsky JL, Wipf P. Rastelli EJ, et al. Among authors: brodsky jl. Bioorg Med Chem Lett. 2021 Aug 15;46:128167. doi: 10.1016/j.bmcl.2021.128167. Epub 2021 Jun 2. Bioorg Med Chem Lett. 2021. PMID: 34089839 Free PMC article.

2

Small molecule modulators of endogenous and co-chaperone-stimulated Hsp70 ATPase activity.

Fewell SW, Smith CM, Lyon MA, Dumitrescu TP, Wipf P, Day BW, Brodsky JL. Fewell SW, et al. Among authors: brodsky jl. J Biol Chem. 2004 Dec 3;279(49):51131-40. doi: 10.1074/jbc.M404857200. Epub 2004 Sep 23. J Biol Chem. 2004. PMID: 15448148 Free article.

3

Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer.

Rodina A, Vilenchik M, Moulick K, Aguirre J, Kim J, Chiang A, Litz J, Clement CC, Kang Y, She Y, Wu N, Felts S, Wipf P, Massague J, Jiang X, Brodsky JL, Krystal GW, Chiosis G. Rodina A, et al. Among authors: brodsky jl. Nat Chem Biol. 2007 Aug;3(8):498-507. doi: 10.1038/nchembio.2007.10. Epub 2007 Jul 1. Nat Chem Biol. 2007. PMID: 17603540

4

Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation.

Wright CM, Chovatiya RJ, Jameson NE, Turner DM, Zhu G, Werner S, Huryn DM, Pipas JM, Day BW, Wipf P, Brodsky JL. Wright CM, et al. Among authors: brodsky jl. Bioorg Med Chem. 2008 Mar 15;16(6):3291-301. doi: 10.1016/j.bmc.2007.12.014. Epub 2007 Dec 14. Bioorg Med Chem. 2008. PMID: 18164205 Free PMC article.

5

A precursor-specific role for Hsp40/Hsc70 during tail-anchored protein integration at the endoplasmic reticulum.

Rabu C, Wipf P, Brodsky JL, High S. Rabu C, et al. Among authors: brodsky jl. J Biol Chem. 2008 Oct 10;283(41):27504-27513. doi: 10.1074/jbc.M804591200. Epub 2008 Jul 29. J Biol Chem. 2008. PMID: 18667436 Free PMC article.

6

Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum.

Chiang AN, Valderramos JC, Balachandran R, Chovatiya RJ, Mead BP, Schneider C, Bell SL, Klein MG, Huryn DM, Chen XS, Day BW, Fidock DA, Wipf P, Brodsky JL. Chiang AN, et al. Among authors: brodsky jl. Bioorg Med Chem. 2009 Feb 15;17(4):1527-33. doi: 10.1016/j.bmc.2009.01.024. Epub 2009 Jan 20. Bioorg Med Chem. 2009. PMID: 19195901 Free PMC article.

7

Post-translational import of protein into the endoplasmic reticulum of a trypanosome: an in vitro system for discovery of anti-trypanosomal chemical entities.

Patham B, Duffy J, Lane A, Davis RC, Wipf P, Fewell SW, Brodsky JL, Mensa-Wilmot K. Patham B, et al. Among authors: brodsky jl. Biochem J. 2009 Apr 15;419(2):507-17. doi: 10.1042/BJ20081787. Biochem J. 2009. PMID: 19196237 Free PMC article.

8

Inhibition of Simian Virus 40 replication by targeting the molecular chaperone function and ATPase activity of T antigen.

Wright CM, Seguin SP, Fewell SW, Zhang H, Ishwad C, Vats A, Lingwood CA, Wipf P, Fanning E, Pipas JM, Brodsky JL. Wright CM, et al. Among authors: brodsky jl. Virus Res. 2009 Apr;141(1):71-80. doi: 10.1016/j.virusres.2008.12.018. Epub 2009 Feb 4. Virus Res. 2009. PMID: 19200446 Free PMC article.

9

Identification of Hsp70 modulators through modeling of the substrate binding domain.

Haney CM, Schneider C, Beck B, Brodsky JL, Dömling A. Haney CM, et al. Among authors: brodsky jl. Bioorg Med Chem Lett. 2009 Jul 15;19(14):3828-31. doi: 10.1016/j.bmcl.2009.04.062. Epub 2009 Apr 20. Bioorg Med Chem Lett. 2009. PMID: 19435667 Free PMC article.

10

Chemical methodology as a source of small-molecule checkpoint inhibitors and heat shock protein 70 (Hsp70) modulators.

Huryn DM, Brodsky JL, Brummond KM, Chambers PG, Eyer B, Ireland AW, Kawasumi M, Laporte MG, Lloyd K, Manteau B, Nghiem P, Quade B, Seguin SP, Wipf P. Huryn DM, et al. Among authors: brodsky jl. Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6757-62. doi: 10.1073/pnas.1015251108. Epub 2011 Apr 18. Proc Natl Acad Sci U S A. 2011. PMID: 21502524 Free PMC article.

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