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[Therapy in pancreatic cancer - and still it moves along!].
Ettrich TJ, Perkhofer L, Seufferlein T. Ettrich TJ, et al. Among authors: perkhofer l. Dtsch Med Wochenschr. 2015 Apr;140(7):508-11. doi: 10.1055/s-0041-101154. Epub 2015 Mar 31. Dtsch Med Wochenschr. 2015. PMID: 25826035 German.
Loss of ATM accelerates pancreatic cancer formation and epithelial-mesenchymal transition.
Russell R, Perkhofer L, Liebau S, Lin Q, Lechel A, Feld FM, Hessmann E, Gaedcke J, Güthle M, Zenke M, Hartmann D, von Figura G, Weissinger SE, Rudolph KL, Möller P, Lennerz JK, Seufferlein T, Wagner M, Kleger A. Russell R, et al. Among authors: perkhofer l. Nat Commun. 2015 Jul 29;6:7677. doi: 10.1038/ncomms8677. Nat Commun. 2015. PMID: 26220524 Free PMC article.
DocOx (AIO-PK0106): a phase II trial of docetaxel and oxaliplatin as a second line systemic therapy in patients with advanced pancreatic ductal adenocarcinoma.
Ettrich TJ, Perkhofer L, von Wichert G, Gress TM, Michl P, Hebart HF, Büchner-Steudel P, Geissler M, Muche R, Danner B, Kächele V, Berger AW, Güthle M, Seufferlein T. Ettrich TJ, et al. Among authors: perkhofer l. BMC Cancer. 2016 Jan 15;16:21. doi: 10.1186/s12885-016-2052-4. BMC Cancer. 2016. PMID: 26772812 Free PMC article. Clinical Trial.
Tbx3 fosters pancreatic cancer growth by increased angiogenesis and activin/nodal-dependent induction of stemness.
Perkhofer L, Walter K, Costa IG, Carrasco MC, Eiseler T, Hafner S, Genze F, Zenke M, Bergmann W, Illing A, Hohwieler M, Köhntop R, Lin Q, Holzmann KH, Seufferlein T, Wagner M, Liebau S, Hermann PC, Kleger A, Müller M. Perkhofer L, et al. Stem Cell Res. 2016 Sep;17(2):367-378. doi: 10.1016/j.scr.2016.08.007. Epub 2016 Aug 10. Stem Cell Res. 2016. PMID: 27632063 Free article.
Human pluripotent stem cell-derived acinar/ductal organoids generate human pancreas upon orthotopic transplantation and allow disease modelling.
Hohwieler M, Illing A, Hermann PC, Mayer T, Stockmann M, Perkhofer L, Eiseler T, Antony JS, Müller M, Renz S, Kuo CC, Lin Q, Sendler M, Breunig M, Kleiderman SM, Lechel A, Zenker M, Leichsenring M, Rosendahl J, Zenke M, Sainz B Jr, Mayerle J, Costa IG, Seufferlein T, Kormann M, Wagner M, Liebau S, Kleger A. Hohwieler M, et al. Among authors: perkhofer l. Gut. 2017 Mar;66(3):473-486. doi: 10.1136/gutjnl-2016-312423. Epub 2016 Sep 15. Gut. 2017. PMID: 27633923 Free PMC article.
ATM Deficiency Generating Genomic Instability Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Therapy-Induced DNA Damage.
Perkhofer L, Schmitt A, Romero Carrasco MC, Ihle M, Hampp S, Ruess DA, Hessmann E, Russell R, Lechel A, Azoitei N, Lin Q, Liebau S, Hohwieler M, Bohnenberger H, Lesina M, Algül H, Gieldon L, Schröck E, Gaedcke J, Wagner M, Wiesmüller L, Sipos B, Seufferlein T, Reinhardt HC, Frappart PO, Kleger A. Perkhofer L, et al. Cancer Res. 2017 Oct 15;77(20):5576-5590. doi: 10.1158/0008-5472.CAN-17-0634. Epub 2017 Aug 8. Cancer Res. 2017. PMID: 28790064
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