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Agrin induces long-term osteochondral regeneration by supporting repair morphogenesis.
Eldridge SE, Barawi A, Wang H, Roelofs AJ, Kaneva M, Guan Z, Lydon H, Thomas BL, Thorup AS, Fernandez BF, Caxaria S, Strachan D, Ali A, Shanmuganathan K, Pitzalis C, Whiteford JR, Henson F, McCaskie AW, De Bari C, Dell'Accio F. Eldridge SE, et al. Among authors: thorup as. Sci Transl Med. 2020 Sep 2;12(559):eaax9086. doi: 10.1126/scitranslmed.aax9086. Sci Transl Med. 2020. PMID: 32878982
ROR2 blockade as a therapy for osteoarthritis.
Thorup AS, Strachan D, Caxaria S, Poulet B, Thomas BL, Eldridge SE, Nalesso G, Whiteford JR, Pitzalis C, Aigner T, Corder R, Bertrand J, Dell'Accio F. Thorup AS, et al. Sci Transl Med. 2020 Sep 16;12(561):eaax3063. doi: 10.1126/scitranslmed.aax3063. Sci Transl Med. 2020. PMID: 32938794
WNT3A-loaded exosomes enable cartilage repair.
Thomas BL, Eldridge SE, Nosrati B, Alvarez M, Thorup AS, Nalesso G, Caxaria S, Barawi A, Nicholson JG, Perretti M, Gaston-Massuet C, Pitzalis C, Maloney A, Moore A, Jupp R, Dell'Accio F. Thomas BL, et al. Among authors: thorup as. J Extracell Vesicles. 2021 May;10(7):e12088. doi: 10.1002/jev2.12088. Epub 2021 May 19. J Extracell Vesicles. 2021. PMID: 34025953 Free PMC article.
Disease modification and symptom relief in osteoarthritis using a mutated GCP-2/CXCL6 chemokine.
Caxaria S, Kouvatsos N, Eldridge SE, Alvarez-Fallas M, Thorup AS, Cici D, Barawi A, Arshed A, Strachan D, Carletti G, Huang X, Bharde S, Deniz M, Wilson J, Thomas BL, Pitzalis C, Cantatore FP, Sayilekshmy M, Sikandar S, Luyten FP, Pap T, Sherwood JC, Day AJ, Dell'Accio F. Caxaria S, et al. Among authors: thorup as. EMBO Mol Med. 2023 Jan 11;15(1):e16218. doi: 10.15252/emmm.202216218. Epub 2022 Dec 12. EMBO Mol Med. 2023. PMID: 36507558 Free PMC article.