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HDAC7 is a major contributor in the pathogenesis of infant t(4;11) proB acute lymphoblastic leukemia.
de Barrios O, Galaras A, Trincado JL, Azagra A, Collazo O, Meler A, Agraz-Doblas A, Bueno C, Ballerini P, Cazzaniga G, Stam RW, Varela I, De Lorenzo P, Valsecchi MG, Hatzis P, Menéndez P, Parra M. de Barrios O, et al. Among authors: azagra a. Leukemia. 2021 Jul;35(7):2086-2091. doi: 10.1038/s41375-020-01097-x. Epub 2020 Dec 1. Leukemia. 2021. PMID: 33262526 No abstract available.
The HDAC7-TET2 epigenetic axis is essential during early B lymphocyte development.
Azagra A, Meler A, de Barrios O, Tomás-Daza L, Collazo O, Monterde B, Obiols M, Rovirosa L, Vila-Casadesús M, Cabrera-Pasadas M, Gusi-Vives M, Graf T, Varela I, Sardina JL, Javierre BM, Parra M. Azagra A, et al. Nucleic Acids Res. 2022 Aug 26;50(15):8471-8490. doi: 10.1093/nar/gkac619. Nucleic Acids Res. 2022. PMID: 35904805 Free PMC article.
In vivo conditional deletion of HDAC7 reveals its requirement to establish proper B lymphocyte identity and development.
Azagra A, Román-González L, Collazo O, Rodríguez-Ubreva J, de Yébenes VG, Barneda-Zahonero B, Rodríguez J, Castro de Moura M, Grego-Bessa J, Fernández-Duran I, Islam AB, Esteller M, Ramiro AR, Ballestar E, Parra M. Azagra A, et al. J Exp Med. 2016 Nov 14;213(12):2591-2601. doi: 10.1084/jem.20150821. Epub 2016 Oct 17. J Exp Med. 2016. PMID: 27810920 Free PMC article.
The transcriptional repressor HDAC7 promotes apoptosis and c-Myc downregulation in particular types of leukemia and lymphoma.
Barneda-Zahonero B, Collazo O, Azagra A, Fernández-Duran I, Serra-Musach J, Islam AB, Vega-García N, Malatesta R, Camós M, Gómez A, Román-González L, Vidal A, López-Bigas N, Villanueva A, Esteller M, Parra M. Barneda-Zahonero B, et al. Among authors: azagra a. Cell Death Dis. 2015 Feb 12;6(2):e1635. doi: 10.1038/cddis.2014.594. Cell Death Dis. 2015. PMID: 25675295 Free PMC article.
Pediatric Acute Lung Injury Epidemiology and Natural History study: Incidence and outcome of the acute respiratory distress syndrome in children.
López-Fernández Y, Azagra AM, de la Oliva P, Modesto V, Sánchez JI, Parrilla J, Arroyo MJ, Reyes SB, Pons-Ódena M, López-Herce J, Fernández RL, Kacmarek RM, Villar J; Pediatric Acute Lung Injury Epidemiology and Natural History (PED-ALIEN) Network. López-Fernández Y, et al. Among authors: azagra am. Crit Care Med. 2012 Dec;40(12):3238-45. doi: 10.1097/CCM.0b013e318260caa3. Crit Care Med. 2012. PMID: 22990455