HDAC7 is a major contributor in the pathogenesis of infant t(4;11) proB acute lymphoblastic leukemia

Oriol de Barrios; Alexandros Galaras; Juan L Trincado; Alba Azagra; Olga Collazo; Ainara Meler; Antonio Agraz-Doblas; Clara Bueno; Paola Ballerini; Giovanni Cazzaniga; Ronald W Stam; Ignacio Varela; Paola De Lorenzo; Maria Grazia Valsecchi; Pantelis Hatzis; Pablo Menéndez; Maribel Parra

doi:10.1038/s41375-020-01097-x

HDAC7 is a major contributor in the pathogenesis of infant t(4;11) proB acute lymphoblastic leukemia

Leukemia. 2021 Jul;35(7):2086-2091. doi: 10.1038/s41375-020-01097-x. Epub 2020 Dec 1.

Authors

Oriol de Barrios^{1

2}, Alexandros Galaras^{3

4}, Juan L Trincado⁵, Alba Azagra^{1

2}, Olga Collazo^{1

2}, Ainara Meler^{1

2}, Antonio Agraz-Doblas^{5

6}, Clara Bueno⁵, Paola Ballerini⁷, Giovanni Cazzaniga⁸, Ronald W Stam⁹, Ignacio Varela⁶, Paola De Lorenzo^{8

10}, Maria Grazia Valsecchi¹⁰, Pantelis Hatzis³, Pablo Menéndez^{5

11

12}, Maribel Parra^{13

14}

Affiliations

¹ Lymphocyte Development and Disease Group, Josep Carreras Leukaemia Research Institute (IJC), Ctra. de Can Ruti, Camí de les Escoles, s/n, 08916, Badalona, Barcelona, Spain.
² Cellular Differentiation Group, Instituto de Investigación Biomédica de Bellvitge (IDIBELL), Barcelona, Spain.
³ Biomedical Sciences Research Center "Alexander Fleming", 16672, Vari, Greece.
⁴ Department of Biochemistry and Biotechnology, University of Thessaly, Larissa, Greece.
⁵ Josep Carreras Leukaemia Research Institute, School of Medicine, University of Barcelona, 08036, Barcelona, Spain.
⁶ Instituto de Biomedicina y Biotecnología de Cantabria, Universidad de Cantabria-CSIC, Santander, Spain.
⁷ Department of Pediatric Hematology, A. Trousseau Hospital, Paris, France.
⁸ Centro Ricerca Tettamanti, Department of Pediatrics, University of Milano-Bicocca, Fondazione MBBM, Monza, Italy.
⁹ Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands.
¹⁰ Interfant Trial Data Center, University of Milano-Bicocca, Monza, Italy.
¹¹ Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.
¹² CIBER-ONC-ISCIII, Barcelona, Spain.
¹³ Lymphocyte Development and Disease Group, Josep Carreras Leukaemia Research Institute (IJC), Ctra. de Can Ruti, Camí de les Escoles, s/n, 08916, Badalona, Barcelona, Spain. mparra@carrerasresearch.org.
¹⁴ Cellular Differentiation Group, Instituto de Investigación Biomédica de Bellvitge (IDIBELL), Barcelona, Spain. mparra@carrerasresearch.org.

PMID: 33262526
DOI: 10.1038/s41375-020-01097-x

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Histone Deacetylases / genetics*
Humans
Infant
Myeloid-Lymphoid Leukemia Protein / genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
Translocation, Genetic / genetics

Substances

Myeloid-Lymphoid Leukemia Protein
HDAC7 protein, human
Histone Deacetylases