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Crystallography-guided discovery of carbazole-based retinoic acid-related orphan receptor gamma-t (RORγt) modulators: insights into different protein behaviors with "short" and "long" inverse agonists.
Yu MC, Yang F, Ding XY, Sun NN, Jiang ZY, Huang YF, Yan YR, Zhu C, Xie Q, Chen ZF, Guo SQ, Jiang HL, Chen KX, Luo C, Luo XM, Chen SJ, Wang YH. Yu MC, et al. Among authors: yan yr. Acta Pharmacol Sin. 2021 Sep;42(9):1524-1534. doi: 10.1038/s41401-020-00552-w. Epub 2020 Nov 25. Acta Pharmacol Sin. 2021. PMID: 33239687 Free PMC article.
Discovery, synthesis, biological evaluation and structure-based optimization of novel piperidine derivatives as acetylcholine-binding protein ligands.
Shen J, Yang XC, Yu MC, Xiao L, Zhang XJ, Sun HJ, Chen H, Pan GX, Yan YR, Wang SC, Li W, Zhou L, Xie Q, Yu LQ, Wang YH, Shao LM. Shen J, et al. Among authors: yan yr. Acta Pharmacol Sin. 2017 Jan;38(1):146-155. doi: 10.1038/aps.2016.124. Epub 2016 Dec 5. Acta Pharmacol Sin. 2017. PMID: 27917874 Free PMC article.
57 results