Clinical Features and Management of Lung Cancer During Pregnancy: A Narrative Review Based on Reported Cases

Jian Ping Zhou; Yi Wang; Ying Ni Lin; Xian Wen Sun; Yong Jie Ding; Ya Ru Yan; Ning Li; Liu Zhang; Qing Yun Li

doi:10.1089/whr.2023.0085

Clinical Features and Management of Lung Cancer During Pregnancy: A Narrative Review Based on Reported Cases

Womens Health Rep (New Rochelle). 2023 Nov 17;4(1):544-550. doi: 10.1089/whr.2023.0085. eCollection 2023.

Authors

Jian Ping Zhou^{1

2}, Yi Wang^{1

2}, Ying Ni Lin^{1

2}, Xian Wen Sun^{1

2}, Yong Jie Ding^{1

2}, Ya Ru Yan^{1

2}, Ning Li^{1

2}, Liu Zhang^{1

2}, Qing Yun Li^{1

2}

Affiliations

¹ Department of Respiratory and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
² Institute of Respiratory Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Abstract

This review aims to provide a summary of the clinical characteristics and outcomes of lung cancer during pregnancy. A comprehensive literature search yielded 93 cases of lung cancer during pregnancy from 1953 to 2022, with an average maternal age of ∼34 years old. The initial symptoms reported were often nonspecific, such as cough, dyspnea, and chest pain. Cancer-related treatments, including surgery, radiotherapy, chemotherapy, and tyrosine kinase inhibitors, have shown beneficial effects on maternal outcomes. A majority of the newborns were born without malformation or diseases, but extended follow-up remains necessary. Early diagnosis of lung cancer is imperative for reducing the risks of placental and fetal metastasis and enhancing overall survival.

Keywords: diagnosis; lung cancer; outcomes; pregnancy; treatment.

Publication types

Review