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Rapid, convenient and efficient kit-independent detection of SARS-CoV-2 RNA.
Michel D, Danzer KM, Groß R, Conzelmann C, Müller JA, Freischmidt A, Weishaupt JH, Heller S, Münch J, Michel M, Stamminger T, Kleger A, Otto M. Michel D, et al. Among authors: kleger a. J Virol Methods. 2020 Dec;286:113965. doi: 10.1016/j.jviromet.2020.113965. Epub 2020 Sep 3. J Virol Methods. 2020. PMID: 32891677 Free PMC article.
Drug Inhibition of SARS-CoV-2 Replication in Human Pluripotent Stem Cell-Derived Intestinal Organoids.
Krüger J, Groß R, Conzelmann C, Müller JA, Koepke L, Sparrer KMJ, Weil T, Schütz D, Seufferlein T, Barth TFE, Stenger S, Heller S, Münch J, Kleger A. Krüger J, et al. Among authors: kleger a. Cell Mol Gastroenterol Hepatol. 2021;11(4):935-948. doi: 10.1016/j.jcmgh.2020.11.003. Epub 2020 Nov 10. Cell Mol Gastroenterol Hepatol. 2021. PMID: 33186749 Free PMC article.
SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas.
Müller JA, Groß R, Conzelmann C, Krüger J, Merle U, Steinhart J, Weil T, Koepke L, Bozzo CP, Read C, Fois G, Eiseler T, Gehrmann J, van Vuuren J, Wessbecher IM, Frick M, Costa IG, Breunig M, Grüner B, Peters L, Schuster M, Liebau S, Seufferlein T, Stenger S, Stenzinger A, MacDonald PE, Kirchhoff F, Sparrer KMJ, Walther P, Lickert H, Barth TFE, Wagner M, Münch J, Heller S, Kleger A. Müller JA, et al. Among authors: kleger a. Nat Metab. 2021 Feb;3(2):149-165. doi: 10.1038/s42255-021-00347-1. Epub 2021 Feb 3. Nat Metab. 2021. PMID: 33536639
Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection.
Wettstein L, Weil T, Conzelmann C, Müller JA, Groß R, Hirschenberger M, Seidel A, Klute S, Zech F, Prelli Bozzo C, Preising N, Fois G, Lochbaum R, Knaff PM, Mailänder V, Ständker L, Thal DR, Schumann C, Stenger S, Kleger A, Lochnit G, Mayer B, Ruiz-Blanco YB, Hoffmann M, Sparrer KMJ, Pöhlmann S, Sanchez-Garcia E, Kirchhoff F, Frick M, Münch J. Wettstein L, et al. Among authors: kleger a. Nat Commun. 2021 Mar 19;12(1):1726. doi: 10.1038/s41467-021-21972-0. Nat Commun. 2021. PMID: 33741941 Free PMC article.
SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies.
Hoffmann M, Arora P, Groß R, Seidel A, Hörnich BF, Hahn AS, Krüger N, Graichen L, Hofmann-Winkler H, Kempf A, Winkler MS, Schulz S, Jäck HM, Jahrsdörfer B, Schrezenmeier H, Müller M, Kleger A, Münch J, Pöhlmann S. Hoffmann M, et al. Among authors: kleger a. Cell. 2021 Apr 29;184(9):2384-2393.e12. doi: 10.1016/j.cell.2021.03.036. Epub 2021 Mar 20. Cell. 2021. PMID: 33794143 Free PMC article.
Human Pluripotent Stem Cells Go Diabetic: A Glimpse on Monogenic Variants.
Heller S, Melzer MK, Azoitei N, Julier C, Kleger A. Heller S, et al. Among authors: kleger a. Front Endocrinol (Lausanne). 2021 May 17;12:648284. doi: 10.3389/fendo.2021.648284. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 34079523 Free PMC article. Review.
IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro.
Prelli Bozzo C, Nchioua R, Volcic M, Koepke L, Krüger J, Schütz D, Heller S, Stürzel CM, Kmiec D, Conzelmann C, Müller J, Zech F, Braun E, Groß R, Wettstein L, Weil T, Weiß J, Diofano F, Rodríguez Alfonso AA, Wiese S, Sauter D, Münch J, Goffinet C, Catanese A, Schön M, Boeckers TM, Stenger S, Sato K, Just S, Kleger A, Sparrer KMJ, Kirchhoff F. Prelli Bozzo C, et al. Among authors: kleger a. Nat Commun. 2021 Jul 28;12(1):4584. doi: 10.1038/s41467-021-24817-y. Nat Commun. 2021. PMID: 34321474 Free PMC article.
Transcriptional changes and the role of ONECUT1 in hPSC pancreatic differentiation.
Heller S, Li Z, Lin Q, Geusz R, Breunig M, Hohwieler M, Zhang X, Nair GG, Seufferlein T, Hebrok M, Sander M, Julier C, Kleger A, Costa IG. Heller S, et al. Among authors: kleger a. Commun Biol. 2021 Nov 17;4(1):1298. doi: 10.1038/s42003-021-02818-3. Commun Biol. 2021. PMID: 34789845 Free PMC article.
155 results