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Deficiency in the glycosyltransferase Gcnt1 increases susceptibility to tuberculosis through a mechanism involving neutrophils.
Fonseca KL, Maceiras AR, Matos R, Simoes-Costa L, Sousa J, Cá B, Barros L, Fernandes AI, Mereiter S, Reis R, Gomes J, Tapia G, Rodríguez-Martínez P, Martín-Céspedes M, Vashakidze S, Gogishvili S, Nikolaishvili K, Appelberg R, Gärtner F, Rodrigues PNS, Vilaplana C, Reis CA, Magalhães A, Saraiva M. Fonseca KL, et al. Among authors: vashakidze s. Mucosal Immunol. 2020 Sep;13(5):836-848. doi: 10.1038/s41385-020-0277-7. Epub 2020 Mar 13. Mucosal Immunol. 2020. PMID: 32203062 Free PMC article.
Additional drug resistance in Mycobacterium tuberculosis isolates from resected cavities among patients with multidrug-resistant or extensively drug-resistant pulmonary tuberculosis.
Kempker RR, Rabin AS, Nikolaishvili K, Kalandadze I, Gogishvili S, Blumberg HM, Vashakidze S. Kempker RR, et al. Among authors: vashakidze s. Clin Infect Dis. 2012 Mar;54(6):e51-4. doi: 10.1093/cid/cir904. Epub 2011 Dec 23. Clin Infect Dis. 2012. PMID: 22198790 Free PMC article.
Cavitary penetration of levofloxacin among patients with multidrug-resistant tuberculosis.
Kempker RR, Barth AB, Vashakidze S, Nikolaishvili K, Sabulua I, Tukvadze N, Bablishvili N, Gogishvili S, Singh RS, Guarner J, Derendorf H, Peloquin CA, Blumberg HM. Kempker RR, et al. Among authors: vashakidze s. Antimicrob Agents Chemother. 2015;59(6):3149-55. doi: 10.1128/AAC.00379-15. Epub 2015 Mar 16. Antimicrob Agents Chemother. 2015. PMID: 25779583 Free PMC article. Clinical Trial.
A comparison of linezolid lung tissue concentrations among patients with drug-resistant tuberculosis.
Kempker RR, Heinrichs MT, Nikolaishvili K, Sabulua I, Bablishvili N, Gogishvili S, Avaliani Z, Little BP, Bernheim A, Derendorf H, Blumberg HM, Vashakidze S, Peloquin CA. Kempker RR, et al. Among authors: vashakidze s. Eur Respir J. 2018 Feb 7;51(2):1702166. doi: 10.1183/13993003.02166-2017. Print 2018 Feb. Eur Respir J. 2018. PMID: 29437945 Free PMC article. No abstract available.
Type I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neutrophil-mediated lung inflammation and NETosis.
Moreira-Teixeira L, Stimpson PJ, Stavropoulos E, Hadebe S, Chakravarty P, Ioannou M, Aramburu IV, Herbert E, Priestnall SL, Suarez-Bonnet A, Sousa J, Fonseca KL, Wang Q, Vashakidze S, Rodríguez-Martínez P, Vilaplana C, Saraiva M, Papayannopoulos V, O'Garra A. Moreira-Teixeira L, et al. Among authors: vashakidze s. Nat Commun. 2020 Nov 4;11(1):5566. doi: 10.1038/s41467-020-19412-6. Nat Commun. 2020. PMID: 33149141 Free PMC article.
Genomic analyses of Mycobacterium tuberculosis from human lung resections reveal a high frequency of polyclonal infections.
Moreno-Molina M, Shubladze N, Khurtsilava I, Avaliani Z, Bablishvili N, Torres-Puente M, Villamayor L, Gabrielian A, Rosenthal A, Vilaplana C, Gagneux S, Kempker RR, Vashakidze S, Comas I. Moreno-Molina M, et al. Among authors: vashakidze s. Nat Commun. 2021 May 11;12(1):2716. doi: 10.1038/s41467-021-22705-z. Nat Commun. 2021. PMID: 33976135 Free PMC article.
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