Abstract
The pathogenesis of increasing drug resistance among patients with multidrug-resistant or extensively drug-resistant tuberculosis undergoing treatment is poorly understood. Increasing drug resistance found among Mycobacterium tuberculosis recovered from cavitary isolates compared with paired sputum isolates suggests pulmonary cavities may play a role in the development of worsening tuberculosis drug resistance.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Antitubercular Agents / pharmacology*
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Drug Resistance, Multiple, Bacterial*
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Extensively Drug-Resistant Tuberculosis / drug therapy
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Extensively Drug-Resistant Tuberculosis / microbiology*
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Extensively Drug-Resistant Tuberculosis / surgery
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Female
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Humans
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Lung / microbiology*
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Male
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Microbial Sensitivity Tests
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Middle Aged
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Mycobacterium tuberculosis / drug effects*
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Mycobacterium tuberculosis / isolation & purification
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Sputum / microbiology*
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Tuberculosis, Multidrug-Resistant / drug therapy
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Tuberculosis, Multidrug-Resistant / microbiology*
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Tuberculosis, Multidrug-Resistant / surgery
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Young Adult