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Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening.
Resnick E, Bradley A, Gan J, Douangamath A, Krojer T, Sethi R, Geurink PP, Aimon A, Amitai G, Bellini D, Bennett J, Fairhead M, Fedorov O, Gabizon R, Gan J, Guo J, Plotnikov A, Reznik N, Ruda GF, Díaz-Sáez L, Straub VM, Szommer T, Velupillai S, Zaidman D, Zhang Y, Coker AR, Dowson CG, Barr HM, Wang C, Huber KVM, Brennan PE, Ovaa H, von Delft F, London N. Resnick E, et al. Among authors: wang c. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22. J Am Chem Soc. 2019. PMID: 31060360 Free PMC article.
Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo.
Dubiella C, Pinch BJ, Koikawa K, Zaidman D, Poon E, Manz TD, Nabet B, He S, Resnick E, Rogel A, Langer EM, Daniel CJ, Seo HS, Chen Y, Adelmant G, Sharifzadeh S, Ficarro SB, Jamin Y, Martins da Costa B, Zimmerman MW, Lian X, Kibe S, Kozono S, Doctor ZM, Browne CM, Yang A, Stoler-Barak L, Shah RB, Vangos NE, Geffken EA, Oren R, Koide E, Sidi S, Shulman Z, Wang C, Marto JA, Dhe-Paganon S, Look T, Zhou XZ, Lu KP, Sears RC, Chesler L, Gray NS, London N. Dubiella C, et al. Among authors: wang c. Nat Chem Biol. 2021 Sep;17(9):954-963. doi: 10.1038/s41589-021-00786-7. Epub 2021 May 10. Nat Chem Biol. 2021. PMID: 33972797 Free PMC article.
Chemoproteomic profiling of itaconations in Salmonella.
Zhang Y, Qin W, Liu D, Liu Y, Wang C. Zhang Y, et al. Among authors: wang c. Chem Sci. 2021 Mar 31;12(17):6059-6063. doi: 10.1039/d1sc00660f. Chem Sci. 2021. PMID: 33996001 Free PMC article.
Discovery of Itaconate-Mediated Lysine Acylation.
Liu D, Xiao W, Li H, Zhang Y, Yuan S, Li C, Dong S, Wang C. Liu D, et al. Among authors: wang c. J Am Chem Soc. 2023 Jun 14;145(23):12673-12681. doi: 10.1021/jacs.3c02332. Epub 2023 Jun 4. J Am Chem Soc. 2023. PMID: 37271942
RosettaDock in CAPRI rounds 6-12.
Wang C, Schueler-Furman O, Andre I, London N, Fleishman SJ, Bradley P, Qian B, Baker D. Wang C, et al. Proteins. 2007 Dec 1;69(4):758-63. doi: 10.1002/prot.21684. Proteins. 2007. PMID: 17671979
102,201 results
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