Discovery of post-translational modifications in immunometabolism by chemical proteomics

Yanling Zhang; Wei Qin; Chu Wang

doi:10.1016/j.copbio.2020.09.013

Discovery of post-translational modifications in immunometabolism by chemical proteomics

Curr Opin Biotechnol. 2021 Apr:68:37-43. doi: 10.1016/j.copbio.2020.09.013. Epub 2020 Oct 24.

Authors

Yanling Zhang¹, Wei Qin¹, Chu Wang²

Affiliations

¹ Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education,Peking University, Beijing 100871, China; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China.
² Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education,Peking University, Beijing 100871, China; College of Chemistry and Molecular Engineering,Peking University, Beijing 100871, China; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China. Electronic address: chuwang@pku.edu.cn.

PMID: 33113497
DOI: 10.1016/j.copbio.2020.09.013

Abstract

Metabolic reprogramming of macrophages during immune activation can generate diversified types of small molecule metabolites, which in turn induce post-translational modifications (PTMs) on proteins. Understanding the functional implications of these modifications requires precise identification of them from complex biological samples. We herein review recent progress in systematic discovery of immunometabolite PTMs by chemical proteomics.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Protein Processing, Post-Translational*
Proteins / genetics
Proteins / metabolism
Proteomics*

Substances

Proteins