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Histone H3.3 K27M Accelerates Spontaneous Brainstem Glioma and Drives Restricted Changes in Bivalent Gene Expression.
Larson JD, Kasper LH, Paugh BS, Jin H, Wu G, Kwon CH, Fan Y, Shaw TI, Silveira AB, Qu C, Xu R, Zhu X, Zhang J, Russell HR, Peters JL, Finkelstein D, Xu B, Lin T, Tinkle CL, Patay Z, Onar-Thomas A, Pounds SB, McKinnon PJ, Ellison DW, Zhang J, Baker SJ. Larson JD, et al. Among authors: mckinnon pj. Cancer Cell. 2019 Jan 14;35(1):140-155.e7. doi: 10.1016/j.ccell.2018.11.015. Epub 2018 Dec 27. Cancer Cell. 2019. PMID: 30595505 Free PMC article.
Apurinic endonuclease-1 preserves neural genome integrity to maintain homeostasis and thermoregulation and prevent brain tumors.
Dumitrache LC, Shimada M, Downing SM, Kwak YD, Li Y, Illuzzi JL, Russell HR, Wilson DM 3rd, McKinnon PJ. Dumitrache LC, et al. Among authors: mckinnon pj. Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):E12285-E12294. doi: 10.1073/pnas.1809682115. Epub 2018 Dec 11. Proc Natl Acad Sci U S A. 2018. PMID: 30538199 Free PMC article.
Subtypes of medulloblastoma have distinct developmental origins.
Gibson P, Tong Y, Robinson G, Thompson MC, Currle DS, Eden C, Kranenburg TA, Hogg T, Poppleton H, Martin J, Finkelstein D, Pounds S, Weiss A, Patay Z, Scoggins M, Ogg R, Pei Y, Yang ZJ, Brun S, Lee Y, Zindy F, Lindsey JC, Taketo MM, Boop FA, Sanford RA, Gajjar A, Clifford SC, Roussel MF, McKinnon PJ, Gutmann DH, Ellison DW, Wechsler-Reya R, Gilbertson RJ. Gibson P, et al. Among authors: mckinnon pj. Nature. 2010 Dec 23;468(7327):1095-9. doi: 10.1038/nature09587. Epub 2010 Dec 8. Nature. 2010. PMID: 21150899 Free PMC article.
ATR maintains select progenitors during nervous system development.
Lee Y, Shull ER, Frappart PO, Katyal S, Enriquez-Rios V, Zhao J, Russell HR, Brown EJ, McKinnon PJ. Lee Y, et al. Among authors: mckinnon pj. EMBO J. 2012 Mar 7;31(5):1177-89. doi: 10.1038/emboj.2011.493. Epub 2012 Jan 20. EMBO J. 2012. PMID: 22266795 Free PMC article.
Slug, a highly conserved zinc finger transcriptional repressor, protects hematopoietic progenitor cells from radiation-induced apoptosis in vivo.
Inoue A, Seidel MG, Wu W, Kamizono S, Ferrando AA, Bronson RT, Iwasaki H, Akashi K, Morimoto A, Hitzler JK, Pestina TI, Jackson CW, Tanaka R, Chong MJ, McKinnon PJ, Inukai T, Grosveld GC, Look AT. Inoue A, et al. Among authors: mckinnon pj. Cancer Cell. 2002 Oct;2(4):279-88. doi: 10.1016/s1535-6108(02)00155-1. Cancer Cell. 2002. PMID: 12398892 Free article.
ATM dependent apoptosis in the nervous system.
Lee Y, McKinnon PJ. Lee Y, et al. Among authors: mckinnon pj. Apoptosis. 2000 Dec;5(6):523-9. doi: 10.1023/a:1009637512917. Apoptosis. 2000. PMID: 11303911 Review.
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