Rashad AA - Search Results

1

Exploring Modifications of an HIV-1 Capsid Inhibitor: Design, Synthesis, and Mechanism of Action.

Xu JP, Francis AC, Meuser ME, Mankowski M, Ptak RG, Rashad AA, Melikyan GB, Cocklin S. Xu JP, et al. Among authors: rashad aa. J Drug Des Res. 2018;5(2):1070. Epub 2018 Aug 13. J Drug Des Res. 2018. PMID: 30393786 Free PMC article.

2

Kinetic Characterization of Novel HIV-1 Entry Inhibitors: Discovery of a Relationship between Off-Rate and Potency.

Meuser ME, Murphy MB, Rashad AA, Cocklin S. Meuser ME, et al. Among authors: rashad aa. Molecules. 2018 Aug 3;23(8):1940. doi: 10.3390/molecules23081940. Molecules. 2018. PMID: 30081466 Free PMC article.

3

Field-Based Affinity Optimization of a Novel Azabicyclohexane Scaffold HIV-1 Entry Inhibitor.

Meuser ME, Rashad AA, Ozorowski G, Dick A, Ward AB, Cocklin S. Meuser ME, et al. Among authors: rashad aa. Molecules. 2019 Apr 22;24(8):1581. doi: 10.3390/molecules24081581. Molecules. 2019. PMID: 31013646 Free PMC article.

4

Selective and brain-penetrant ACSS2 inhibitors target breast cancer brain metastatic cells.

Esquea EM, Ciraku L, Young RG, Merzy J, Talarico AN, Ahmed NN, Karuppiah M, Ramesh A, Chatoff A, Crispim CV, Rashad AA, Cocklin S, Snyder NW, Beld J, Simone NL, Reginato MJ, Dick A. Esquea EM, et al. Among authors: rashad aa. Front Pharmacol. 2024 May 16;15:1394685. doi: 10.3389/fphar.2024.1394685. eCollection 2024. Front Pharmacol. 2024. PMID: 38818373 Free PMC article.

5

Discovery of novel brain permeable human ACSS2 inhibitors for blocking breast cancer brain metastatic growth.

Esquea E, Ciraku L, Young RG, Merzy J, Talarico AN, Rashad AA, Cocklin S, Simone NL, Beld J, Reginato MJ, Dick A. Esquea E, et al. Among authors: rashad aa. bioRxiv [Preprint]. 2023 Dec 23:2023.12.22.573073. doi: 10.1101/2023.12.22.573073. bioRxiv. 2023. PMID: 38187734 Free PMC article. Preprint.

6

Discovery of a first-in-class inhibitor of sulfide:quinone oxidoreductase that protects against adverse cardiac remodelling and heart failure.

Jackson MR, Cox KD, Baugh SDP, Wakeen L, Rashad AA, Lam PYS, Polyak B, Jorns MS. Jackson MR, et al. Among authors: rashad aa. Cardiovasc Res. 2022 Jun 22;118(7):1771-1784. doi: 10.1093/cvr/cvab206. Cardiovasc Res. 2022. PMID: 34132787 Free PMC article.

7

Altered Env conformational dynamics as a mechanism of resistance to peptide-triazole HIV-1 inactivators.

Zhang S, Holmes AP, Dick A, Rashad AA, Enríquez Rodríguez L, Canziani GA, Root MJ, Chaiken IM. Zhang S, et al. Among authors: rashad aa. Retrovirology. 2021 Oct 9;18(1):31. doi: 10.1186/s12977-021-00575-z. Retrovirology. 2021. PMID: 34627310 Free PMC article.

8

Peptide triazole inactivators of HIV-1: how do they work and what is their potential?

Chaiken I, Rashad AA. Chaiken I, et al. Among authors: rashad aa. Future Med Chem. 2015;7(17):2305-10. doi: 10.4155/fmc.15.152. Epub 2015 Nov 24. Future Med Chem. 2015. PMID: 26599515 Free PMC article. No abstract available.

9

Recognition of HIV-inactivating peptide triazoles by the recombinant soluble Env trimer, BG505 SOSIP.664.

Acharya K, Rashad AA, Moraca F, Klasse PJ, Moore JP, Abrams C, Chaiken I. Acharya K, et al. Among authors: rashad aa. Proteins. 2017 May;85(5):843-851. doi: 10.1002/prot.25238. Epub 2017 Mar 11. Proteins. 2017. PMID: 28056499 Free PMC article.

10

Chemical optimization of macrocyclic HIV-1 inactivators for improving potency and increasing the structural diversity at the triazole ring.

Rashad AA, Acharya K, Haftl A, Aneja R, Dick A, Holmes AP, Chaiken I. Rashad AA, et al. Org Biomol Chem. 2017 Sep 26;15(37):7770-7782. doi: 10.1039/c7ob01448a. Org Biomol Chem. 2017. PMID: 28770939 Free PMC article.

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