Peptide triazole inactivators of HIV-1: how do they work and what is their potential?

Future Med Chem. 2015;7(17):2305-10. doi: 10.4155/fmc.15.152. Epub 2015 Nov 24.
No abstract available

Keywords: AIDS; HIV-1; cell entry; envelope protein antagonism; infection inhibition; macrocycle; peptidomimetics; virus inactivation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Anti-HIV Agents / chemistry*
  • Anti-HIV Agents / pharmacology
  • Catalysis
  • Copper / chemistry
  • Cycloaddition Reaction
  • HIV Envelope Protein gp120 / antagonists & inhibitors
  • HIV Envelope Protein gp120 / metabolism
  • HIV-1 / drug effects
  • HIV-1 / metabolism*
  • Humans
  • Peptides / chemistry*
  • Triazoles / chemistry*
  • Virus Internalization / drug effects

Substances

  • Anti-HIV Agents
  • HIV Envelope Protein gp120
  • Peptides
  • Triazoles
  • Copper