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Synthesis, Binding Mode, and Antihyperglycemic Activity of Potent and Selective (5-Imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine Inhibitors of Glycogen Synthase Kinase 3.
Wagman AS, Boyce RS, Brown SP, Fang E, Goff D, Jansen JM, Le VP, Levine BH, Ng SC, Ni ZJ, Nuss JM, Pfister KB, Ramurthy S, Renhowe PA, Ring DB, Shu W, Subramanian S, Zhou XA, Shafer CM, Harrison SD, Johnson KW, Bussiere DE. Wagman AS, et al. Among authors: goff d. J Med Chem. 2017 Oct 26;60(20):8482-8514. doi: 10.1021/acs.jmedchem.7b00922. Epub 2017 Oct 10. J Med Chem. 2017. PMID: 29016121
Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 5. Structure-activity relationships for side-chain nitro-, sulfone-, amino-, and aminosulfonyl-substituted analogues for therapy against anticholinesterase intoxication.
Koolpe GA, Lovejoy SM, Goff DA, Lin KY, Leung DS, Bedford CD, Musallam HA, Koplovitz I, Harris RN 3rd. Koolpe GA, et al. Among authors: goff da. J Med Chem. 1991 Apr;34(4):1368-76. doi: 10.1021/jm00108a020. J Med Chem. 1991. PMID: 2016712
Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 2. Preparation and in vitro and in vivo evaluation of 1-(alkoxymethyl)-2-[(hydroxyimino)methyl]-3-methylimida zolium halides for reactivation of organophosphorus-inhibited acetylcholinesterases.
Bedford CD, Harris RN 3rd, Howd RA, Goff DA, Koolpe GA, Petesch M, Miller A, Nolen HW 3rd, Musallam HA, Pick RO, et al. Bedford CD, et al. Among authors: goff da. J Med Chem. 1989 Feb;32(2):493-503. doi: 10.1021/jm00122a034. J Med Chem. 1989. PMID: 2913310
Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 3. Synthesis and evaluation of (alkenyloxy)-, (alkynyloxy)-, and (aralkyloxy)methyl quaternarized 2-[(hydroxyimino)methyl]-1-alkylimidazolium halides as reactivators and therapy for soman intoxication.
Bedford CD, Harris RN 3rd, Howd RA, Goff DA, Koolpe GA, Petesch M, Koplovitz I, Sultan WE, Musallam HA. Bedford CD, et al. Among authors: goff da. J Med Chem. 1989 Feb;32(2):504-16. doi: 10.1021/jm00122a035. J Med Chem. 1989. PMID: 2913311
996 results