Antimalarial phenanthrene amino alcohols. 3. Halogen-containing 9-phenanthrenemethanols

E A Nodiff; A J Saggiomo; K Tanabe; E H Chen; M Shinbo; M P Tyagi; A Kozuka; H Otomasu; B L Verma; D Goff

doi:10.1021/jm00244a012

Antimalarial phenanthrene amino alcohols. 3. Halogen-containing 9-phenanthrenemethanols

J Med Chem. 1975 Oct;18(10):1011-9. doi: 10.1021/jm00244a012.

Authors

E A Nodiff, A J Saggiomo, K Tanabe, E H Chen, M Shinbo, M P Tyagi, A Kozuka, H Otomasu, B L Verma, D Goff

PMID: 1099200
DOI: 10.1021/jm00244a012

Abstract

A series of new 9-phenanthrene amino alcohols has been prepared in which each compound bears from one to five halogen or halogen-containing moieties. A number of these compounds are extremely active against Plasmodium berghei in the mouse. Some structural requirements for optimal efficacy are considered.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Amino Alcohols / chemical synthesis
Amino Alcohols / therapeutic use
Animals
Antimalarials / chemical synthesis*
Antimalarials / therapeutic use
Chickens
Halogens / therapeutic use
Malaria / drug therapy
Malaria, Avian / drug therapy
Mice
Phenanthrenes / chemical synthesis*
Phenanthrenes / therapeutic use
Plasmodium berghei
Structure-Activity Relationship

Substances

Amino Alcohols
Antimalarials
Halogens
Phenanthrenes