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Bixin regulates mRNA expression involved in adipogenesis and enhances insulin sensitivity in 3T3-L1 adipocytes through PPARgamma activation.
Takahashi N, Goto T, Taimatsu A, Egawa K, Katoh S, Kusudo T, Sakamoto T, Ohyane C, Lee JY, Kim YI, Uemura T, Hirai S, Kawada T. Takahashi N, et al. Among authors: kawada t. Biochem Biophys Res Commun. 2009 Dec 25;390(4):1372-6. doi: 10.1016/j.bbrc.2009.10.162. Epub 2009 Nov 3. Biochem Biophys Res Commun. 2009. PMID: 19891958
Activation of peroxisome proliferator-activated receptor-α (PPARα) suppresses postprandial lipidemia through fatty acid oxidation in enterocytes.
Kimura R, Takahashi N, Murota K, Yamada Y, Niiya S, Kanzaki N, Murakami Y, Moriyama T, Goto T, Kawada T. Kimura R, et al. Among authors: kawada t. Biochem Biophys Res Commun. 2011 Jun 24;410(1):1-6. doi: 10.1016/j.bbrc.2011.05.057. Epub 2011 May 25. Biochem Biophys Res Commun. 2011. PMID: 21640707 Free article.
10-oxo-12(Z)-octadecenoic acid, a linoleic acid metabolite produced by gut lactic acid bacteria, potently activates PPARγ and stimulates adipogenesis.
Goto T, Kim YI, Furuzono T, Takahashi N, Yamakuni K, Yang HE, Li Y, Ohue R, Nomura W, Sugawara T, Yu R, Kitamura N, Park SB, Kishino S, Ogawa J, Kawada T. Goto T, et al. Among authors: kawada t. Biochem Biophys Res Commun. 2015 Apr 17;459(4):597-603. doi: 10.1016/j.bbrc.2015.02.154. Epub 2015 Mar 5. Biochem Biophys Res Commun. 2015. PMID: 25749343
The hepatokine FGF21 is crucial for peroxisome proliferator-activated receptor-α agonist-induced amelioration of metabolic disorders in obese mice.
Goto T, Hirata M, Aoki Y, Iwase M, Takahashi H, Kim M, Li Y, Jheng HF, Nomura W, Takahashi N, Kim CS, Yu R, Seno S, Matsuda H, Aizawa-Abe M, Ebihara K, Itoh N, Kawada T. Goto T, et al. Among authors: kawada t. J Biol Chem. 2017 Jun 2;292(22):9175-9190. doi: 10.1074/jbc.M116.767590. Epub 2017 Apr 12. J Biol Chem. 2017. PMID: 28404815 Free PMC article.
A Phytol-Enriched Diet Activates PPAR-α in the Liver and Brown Adipose Tissue to Ameliorate Obesity-Induced Metabolic Abnormalities.
An JY, Jheng HF, Nagai H, Sanada K, Takahashi H, Iwase M, Watanabe N, Kim YI, Teraminami A, Takahashi N, Nakata R, Inoue H, Seno S, Mastuda H, Kawada T, Goto T. An JY, et al. Among authors: kawada t. Mol Nutr Food Res. 2018 Mar;62(6):e1700688. doi: 10.1002/mnfr.201700688. Epub 2018 Feb 22. Mol Nutr Food Res. 2018. PMID: 29377597
Phytol directly activates peroxisome proliferator-activated receptor alpha (PPARalpha) and regulates gene expression involved in lipid metabolism in PPARalpha-expressing HepG2 hepatocytes.
Goto T, Takahashi N, Kato S, Egawa K, Ebisu S, Moriyama T, Fushiki T, Kawada T. Goto T, et al. Among authors: kawada t. Biochem Biophys Res Commun. 2005 Nov 18;337(2):440-5. doi: 10.1016/j.bbrc.2005.09.077. Epub 2005 Sep 21. Biochem Biophys Res Commun. 2005. PMID: 16202384
2,109 results