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High mTOR activity is a hallmark of reactive natural killer cells and amplifies early signaling through activating receptors.
Elife. 2017 Sep 6;6:e26423. doi: 10.7554/eLife.26423.
Elife. 2017.
PMID: 28875936
Free PMC article.
The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells.
Marçais A, Cherfils-Vicini J, Viant C, Degouve S, Viel S, Fenis A, Rabilloud J, Mayol K, Tavares A, Bienvenu J, Gangloff YG, Gilson E, Vivier E, Walzer T.
Marçais A, et al. Among authors: degouve s.
Nat Immunol. 2014 Aug;15(8):749-757. doi: 10.1038/ni.2936. Epub 2014 Jun 29.
Nat Immunol. 2014.
PMID: 24973821
Free PMC article.
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TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway.
Viel S, Marçais A, Guimaraes FS, Loftus R, Rabilloud J, Grau M, Degouve S, Djebali S, Sanlaville A, Charrier E, Bienvenu J, Marie JC, Caux C, Marvel J, Town L, Huntington ND, Bartholin L, Finlay D, Smyth MJ, Walzer T.
Viel S, et al. Among authors: degouve s.
Sci Signal. 2016 Feb 16;9(415):ra19. doi: 10.1126/scisignal.aad1884.
Sci Signal. 2016.
PMID: 26884601
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NKp46-mediated Dicer1 inactivation results in defective NK-cell differentiation and effector functions in mice.
Degouve S, Tavares A, Viel S, Walzer T, Marçais A.
Degouve S, et al.
Eur J Immunol. 2016 Aug;46(8):1902-11. doi: 10.1002/eji.201546163. Epub 2016 Jun 8.
Eur J Immunol. 2016.
PMID: 27195970
Free article.
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Terminal NK cell maturation is controlled by concerted actions of T-bet and Zeb2 and is essential for melanoma rejection.
van Helden MJ, Goossens S, Daussy C, Mathieu AL, Faure F, Marçais A, Vandamme N, Farla N, Mayol K, Viel S, Degouve S, Debien E, Seuntjens E, Conidi A, Chaix J, Mangeot P, de Bernard S, Buffat L, Haigh JJ, Huylebroeck D, Lambrecht BN, Berx G, Walzer T.
van Helden MJ, et al. Among authors: degouve s.
J Exp Med. 2015 Nov 16;212(12):2015-25. doi: 10.1084/jem.20150809. Epub 2015 Oct 26.
J Exp Med. 2015.
PMID: 26503444
Free PMC article.
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