Trail PA - Search Results

1

Antibody drug conjugates for treatment of breast cancer: Novel targets and diverse approaches in ADC design.

Trail PA, Dubowchik GM, Lowinger TB. Trail PA, et al. Pharmacol Ther. 2018 Jan;181:126-142. doi: 10.1016/j.pharmthera.2017.07.013. Epub 2017 Jul 27. Pharmacol Ther. 2018. PMID: 28757155 Review.

2

Monoclonal antibody mediated intracellular targeting of tallysomycin S(10b).

Walker MA, King HD, Dalterio RA, Trail P, Firestone R, Dubowchik GM. Walker MA, et al. Bioorg Med Chem Lett. 2004 Aug 16;14(16):4323-7. doi: 10.1016/j.bmcl.2004.05.089. Bioorg Med Chem Lett. 2004. PMID: 15261295

3

Doxorubicin immunoconjugates containing bivalent, lysosomally-cleavable dipeptide linkages.

Dubowchik GM, Radia S, Mastalerz H, Walker MA, Firestone RA, Dalton King H, Hofstead SJ, Willner D, Lasch SJ, Trail PA. Dubowchik GM, et al. Among authors: trail pa. Bioorg Med Chem Lett. 2002 Jun 3;12(11):1529-32. doi: 10.1016/s0960-894x(02)00194-4. Bioorg Med Chem Lett. 2002. PMID: 12031335

4

Monoclonal antibody conjugates of doxorubicin prepared with branched peptide linkers: inhibition of aggregation by methoxytriethyleneglycol chains.

King HD, Dubowchik GM, Mastalerz H, Willner D, Hofstead SJ, Firestone RA, Lasch SJ, Trail PA. King HD, et al. Among authors: trail pa. J Med Chem. 2002 Sep 12;45(19):4336-43. doi: 10.1021/jm020149g. J Med Chem. 2002. PMID: 12213074

5

Monoclonal antibody drug immunoconjugates for targeted treatment of cancer.

Trail PA, King HD, Dubowchik GM. Trail PA, et al. Cancer Immunol Immunother. 2003 May;52(5):328-37. doi: 10.1007/s00262-002-0352-9. Epub 2003 Jan 16. Cancer Immunol Immunother. 2003. PMID: 12700948 Free PMC article. Review.

6

Synthesis of an immunoconjugate of camptothecin.

Walker MA, Dubowchik GM, Hofstead SJ, Trail PA, Firestone RA. Walker MA, et al. Among authors: trail pa. Bioorg Med Chem Lett. 2002 Jan 21;12(2):217-9. doi: 10.1016/s0960-894x(01)00707-7. Bioorg Med Chem Lett. 2002. PMID: 11755358

7

Cathepsin B-labile dipeptide linkers for lysosomal release of doxorubicin from internalizing immunoconjugates: model studies of enzymatic drug release and antigen-specific in vitro anticancer activity.

Dubowchik GM, Firestone RA, Padilla L, Willner D, Hofstead SJ, Mosure K, Knipe JO, Lasch SJ, Trail PA. Dubowchik GM, et al. Among authors: trail pa. Bioconjug Chem. 2002 Jul-Aug;13(4):855-69. doi: 10.1021/bc025536j. Bioconjug Chem. 2002. PMID: 12121142

8

Preclinical Activity of the Novel Anti-Prolactin Receptor (PRLR) Antibody-Drug Conjugate REGN2878-DM1 in PRLR-Positive Breast Cancers.

Kelly MP, Hickey C, Makonnen S, Coetzee S, Jalal S, Wang Y, Delfino F, Shan J, Potocky TB, Chatterjee I, Andreev J, Kunz A, D'Souza C, Giurleo JT, Nittoli T, Trail PA, Thurston G, Kirshner JR. Kelly MP, et al. Among authors: trail pa. Mol Cancer Ther. 2017 Jul;16(7):1299-1311. doi: 10.1158/1535-7163.MCT-16-0839. Epub 2017 Apr 4. Mol Cancer Ther. 2017. PMID: 28377489

9

Monoclonal antibody drug conjugates in the treatment of cancer.

Trail PA, Bianchi AB. Trail PA, et al. Curr Opin Immunol. 1999 Oct;11(5):584-8. doi: 10.1016/s0952-7915(99)00012-6. Curr Opin Immunol. 1999. PMID: 10508711 Review.

10

Monoclonal antibody conjugates of doxorubicin prepared with branched linkers: A novel method for increasing the potency of doxorubicin immunoconjugates.

King HD, Yurgaitis D, Willner D, Firestone RA, Yang MB, Lasch SJ, Hellström KE, Trail PA. King HD, et al. Among authors: trail pa. Bioconjug Chem. 1999 Mar-Apr;10(2):279-88. doi: 10.1021/bc980100i. Bioconjug Chem. 1999. PMID: 10077478

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