Chen YL - Search Results

1

Absorption, distribution, metabolism, and excretion of [¹⁴C]-dasotraline in humans.

Chen YL, Skende E, Lin J, Yi Y, Wang PL, Wills S, Wilkinson HS, Koblan KS, Hopkins SC. Chen YL, et al. Pharmacol Res Perspect. 2016 Dec 18;5(1):e00281. doi: 10.1002/prp2.281. eCollection 2017 Feb. Pharmacol Res Perspect. 2016. PMID: 28596833 Free PMC article.

2

A sensitive liquid chromatography-tandem mass spectrometry method for quantitative determination of dasotraline in human plasma and its clinical application.

Skende E, Zheng N, Chen YL. Skende E, et al. Among authors: chen yl. J Pharm Biomed Anal. 2020 Nov 30;191:113611. doi: 10.1016/j.jpba.2020.113611. Epub 2020 Sep 8. J Pharm Biomed Anal. 2020. PMID: 33007733

3

A sensitive LC-MS/MS method for simultaneous quantification of ulotaront and its N-desmethyl metabolite in human plasma and application to a clinical study.

Chen YL, Shi Y, LaFayette A, Shi L, Koblan KS, Galluppi GR. Chen YL, et al. J Pharm Biomed Anal. 2022 Jan 5;207:114404. doi: 10.1016/j.jpba.2021.114404. Epub 2021 Oct 6. J Pharm Biomed Anal. 2022. PMID: 34700199 Free article.

4

Investigation of Human in vivo Metabolism of SEP-227900 Using the Samples from First-in-Human Study by LC-HRMS/UV and NMR.

Chen YL, Skende E, Wetie AGN, Wang PL. Chen YL, et al. Drug Metab Bioanal Lett. 2022;15(1):38-50. doi: 10.2174/1872312815666220302161959. Drug Metab Bioanal Lett. 2022. PMID: 35236276

5

In Vitro ADME and Preclinical Pharmacokinetics of Ulotaront, a TAAR1/5-HT_1A Receptor Agonist for the Treatment of Schizophrenia.

Xiao G, Chen YL, Dedic N, Xie L, Koblan KS, Galluppi GR. Xiao G, et al. Among authors: chen yl. Pharm Res. 2022 May;39(5):837-850. doi: 10.1007/s11095-022-03267-1. Epub 2022 Apr 28. Pharm Res. 2022. PMID: 35484370 Free PMC article.

6

Comparative Bioequivalence of Tablet and Capsule Formulations of Ulotaront and the Effect of Food on the Pharmacokinetics of the Tablet Form in Humans.

Chen YL, Tsukada H, Milanovic S, Shi L, Li Y, Mao Y, Koblan KS, Galluppi GR. Chen YL, et al. Neurol Ther. 2023 Jun;12(3):815-832. doi: 10.1007/s40120-023-00459-8. Epub 2023 Mar 17. Neurol Ther. 2023. PMID: 36932300 Free PMC article.

7

Evaluation of OCT2-mediated drug-drug interactions between ulotaront and metformin in subjects with schizophrenia.

Xiao G, Tsukada H, Chen YL, Shi L, Hopkins SC, Galluppi GR. Xiao G, et al. Among authors: chen yl. Pharmacol Res Perspect. 2024 Apr;12(2):e1191. doi: 10.1002/prp2.1191. Pharmacol Res Perspect. 2024. PMID: 38527949 Free PMC article. Clinical Trial.

8

Exploratory Biomarker Study of the Triple Reuptake Inhibitor SEP-432 Compared to the Dual Reuptake Inhibitor Duloxetine in Healthy Normal Subjects.

Sramek JJ, Hardy LW, Bieck P, Zamora C, Versavel M, Kharidia J, Grinnell T, Chen YL, Sullivan M, Ding H, Cutler NR. Sramek JJ, et al. Among authors: chen yl. CNS Neurosci Ther. 2016 May;22(5):404-12. doi: 10.1111/cns.12513. Epub 2016 Feb 5. CNS Neurosci Ther. 2016. PMID: 26849844 Free PMC article. Clinical Trial.

9

LC-MS/MS simultaneous quantification of apomorphine and its major metabolites in human plasma: Application to clinical comparative bioavailability evaluation for the apomorphine sublingual film and a subcutaneous product.

Chen YL, Shi L, Agbo F, Yong SH, Tan PS, Ngounou Wetie AG. Chen YL, et al. J Pharm Biomed Anal. 2020 Oct 25;190:113493. doi: 10.1016/j.jpba.2020.113493. Epub 2020 Jul 26. J Pharm Biomed Anal. 2020. PMID: 32795778

10

Validation of a sensitive and specific LC-MS/MS method and application to evaluate the systemic exposure and bioavailability of glycopyrrolate via different drug delivery approaches/devices.

Shi L, Ngounou Wetie AG, Wang W, Chen YL. Shi L, et al. Among authors: chen yl. Biomed Chromatogr. 2020 Sep;34(9):e4899. doi: 10.1002/bmc.4899. Epub 2020 Jun 16. Biomed Chromatogr. 2020. PMID: 32428247 Clinical Trial.

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