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ISG15 deficiency and increased viral resistance in humans but not mice.
Speer SD, Li Z, Buta S, Payelle-Brogard B, Qian L, Vigant F, Rubino E, Gardner TJ, Wedeking T, Hermann M, Duehr J, Sanal O, Tezcan I, Mansouri N, Tabarsi P, Mansouri D, Francois-Newton V, Daussy CF, Rodriguez MR, Lenschow DJ, Freiberg AN, Tortorella D, Piehler J, Lee B, García-Sastre A, Pellegrini S, Bogunovic D. Speer SD, et al. Among authors: piehler j. Nat Commun. 2016 May 19;7:11496. doi: 10.1038/ncomms11496. Nat Commun. 2016. PMID: 27193971 Free PMC article.
STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling.
Arimoto KI, Löchte S, Stoner SA, Burkart C, Zhang Y, Miyauchi S, Wilmes S, Fan JB, Heinisch JJ, Li Z, Yan M, Pellegrini S, Colland F, Piehler J, Zhang DE. Arimoto KI, et al. Among authors: piehler j. Nat Struct Mol Biol. 2017 Mar;24(3):279-289. doi: 10.1038/nsmb.3378. Epub 2017 Feb 6. Nat Struct Mol Biol. 2017. PMID: 28165510 Free PMC article.
Type I IFN is siloed in endosomes.
Altman JB, Taft J, Wedeking T, Gruber CN, Holtmannspötter M, Piehler J, Bogunovic D. Altman JB, et al. Among authors: piehler j. Proc Natl Acad Sci U S A. 2020 Jul 28;117(30):17510-17512. doi: 10.1073/pnas.1921324117. Epub 2020 Jul 14. Proc Natl Acad Sci U S A. 2020. PMID: 32665439 Free PMC article.
The receptor of the type I interferon family.
Uzé G, Schreiber G, Piehler J, Pellegrini S. Uzé G, et al. Among authors: piehler j. Curr Top Microbiol Immunol. 2007;316:71-95. doi: 10.1007/978-3-540-71329-6_5. Curr Top Microbiol Immunol. 2007. PMID: 17969444 Review.
High efficiency cell-specific targeting of cytokine activity.
Garcin G, Paul F, Staufenbiel M, Bordat Y, Van der Heyden J, Wilmes S, Cartron G, Apparailly F, De Koker S, Piehler J, Tavernier J, Uzé G. Garcin G, et al. Among authors: piehler j. Nat Commun. 2014;5:3016. doi: 10.1038/ncomms4016. Nat Commun. 2014. PMID: 24398568 Free article.
256 results