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Page 1
An efficient synthetic method and theoretical calculations of olmesartan methyl ether: study of biological function of AT1 antagonism.
Ntountaniotis D, Agelis G, Resvani A, Halabalaki M, Liapakis G, Spyridaki K, Grdadolnik SG, Merzel F, Kostidis S, Potamitis C, Tselios T, Matsoukas J, Skaltsounis LA, Mavromoustakos T. Ntountaniotis D, et al. Among authors: grdadolnik sg. Comb Chem High Throughput Screen. 2014;17(8):652-62. doi: 10.2174/138620731708140922171503. Comb Chem High Throughput Screen. 2014. PMID: 24875271
Thermal, dynamic and structural properties of drug AT1 antagonist olmesartan in lipid bilayers.
Ntountaniotis D, Mali G, Grdadolnik SG, Halabalaki M, Skaltsounis AL, Potamitis C, Siapi E, Chatzigeorgiou P, Rappolt M, Mavromoustakos T. Ntountaniotis D, et al. Among authors: grdadolnik sg. Biochim Biophys Acta. 2011 Dec;1808(12):2995-3006. doi: 10.1016/j.bbamem.2011.08.001. Epub 2011 Aug 6. Biochim Biophys Acta. 2011. PMID: 21843501 Free article.
Rational design, efficient syntheses and biological evaluation of N,N'-symmetrically bis-substituted butylimidazole analogs as a new class of potent Angiotensin II receptor blockers.
Agelis G, Resvani A, Koukoulitsa C, Tůmová T, Slaninová J, Kalavrizioti D, Spyridaki K, Afantitis A, Melagraki G, Siafaka A, Gkini E, Megariotis G, Grdadolnik SG, Papadopoulos MG, Vlahakos D, Maragoudakis M, Liapakis G, Mavromoustakos T, Matsoukas J. Agelis G, et al. Among authors: grdadolnik sg. Eur J Med Chem. 2013 Apr;62:352-70. doi: 10.1016/j.ejmech.2012.12.044. Epub 2013 Jan 2. Eur J Med Chem. 2013. PMID: 23376252 Free article.
Comparison of proposed putative active conformations of myelin basic protein epitope 87-99 linear altered peptide ligands by spectroscopic and modelling studies: the role of positions 91 and 96 in T-cell receptor activation.
Mantzourani ED, Tselios TV, Grdadolnik SG, Platts JA, Brancale A, Deraos GN, Matsoukas JM, Mavromoustakos TM. Mantzourani ED, et al. Among authors: grdadolnik sg. J Med Chem. 2006 Nov 16;49(23):6683-91. doi: 10.1021/jm060040z. J Med Chem. 2006. PMID: 17154499
Antihypertensive drug valsartan in solution and at the AT1 receptor: conformational analysis, dynamic NMR spectroscopy, in silico docking, and molecular dynamics simulations.
Potamitis C, Zervou M, Katsiaras V, Zoumpoulakis P, Durdagi S, Papadopoulos MG, Hayes JM, Grdadolnik SG, Kyrikou I, Argyropoulos D, Vatougia G, Mavromoustakos T. Potamitis C, et al. Among authors: grdadolnik sg. J Chem Inf Model. 2009 Mar;49(3):726-39. doi: 10.1021/ci800427s. J Chem Inf Model. 2009. PMID: 19256500
Conformational and biological studies for a pair of novel synthetic AT1 antagonists: stereoelectronic requirements for antihypertensive efficacy.
Zoumpoulakis P, Zoga A, Roumelioti P, Giatas N, Grdadolnik SG, Iliodromitis E, Vlahakos D, Kremastinos D, Matsoukas JM, Mavromoustakos T. Zoumpoulakis P, et al. Among authors: grdadolnik sg. J Pharm Biomed Anal. 2003 Apr 1;31(5):833-44. doi: 10.1016/s0731-7085(02)00655-6. J Pharm Biomed Anal. 2003. PMID: 12684096
Design, synthesis and biological evaluation of cyclic angiotensin II analogues with 3,5 side-chain bridges. Role of C-terminal aromatic residue and ring cluster for activity and implications in the drug design of AT1 non-peptide antagonists.
Roumelioti P, Polevaya L, Zoumpoulakis P, Giatas N, Mutule I, Keivish T, Zoga A, Vlahakos D, Iliodromitis E, Kremastinos D, Grdadolnik SG, Mavromoustakos T, Matsoukas J. Roumelioti P, et al. Among authors: grdadolnik sg. Bioorg Med Chem Lett. 2002 Sep 16;12(18):2627-33. doi: 10.1016/s0960-894x(02)00474-2. Bioorg Med Chem Lett. 2002. PMID: 12182875
51 results