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Embryonic stem cell-derived motoneurons provide a highly sensitive cell culture model for botulinum neurotoxin studies, with implications for high-throughput drug discovery.
Kiris E, Nuss JE, Burnett JC, Kota KP, Koh DC, Wanner LM, Torres-Melendez E, Gussio R, Tessarollo L, Bavari S. Kiris E, et al. Among authors: burnett jc. Stem Cell Res. 2011 May;6(3):195-205. doi: 10.1016/j.scr.2011.01.002. Epub 2011 Jan 19. Stem Cell Res. 2011. PMID: 21353660 Free PMC article.
Phosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based Assays.
Kiris E, Nuss JE, Stanford SM, Wanner LM, Cazares L, Maestre MF, Du HT, Gomba GY, Burnett JC, Gussio R, Bottini N, Panchal RG, Kane CD, Tessarollo L, Bavari S. Kiris E, et al. Among authors: burnett jc. PLoS One. 2015 Jun 10;10(6):e0129264. doi: 10.1371/journal.pone.0129264. eCollection 2015. PLoS One. 2015. PMID: 26061731 Free PMC article.
Novel small molecule inhibitors of botulinum neurotoxin A metalloprotease activity.
Burnett JC, Schmidt JJ, Stafford RG, Panchal RG, Nguyen TL, Hermone AR, Vennerstrom JL, McGrath CF, Lane DJ, Sausville EA, Zaharevitz DW, Gussio R, Bavari S. Burnett JC, et al. Biochem Biophys Res Commun. 2003 Oct 10;310(1):84-93. doi: 10.1016/j.bbrc.2003.08.112. Biochem Biophys Res Commun. 2003. PMID: 14511652
Inhibition of metalloprotease botulinum serotype A from a pseudo-peptide binding mode to a small molecule that is active in primary neurons.
Burnett JC, Ruthel G, Stegmann CM, Panchal RG, Nguyen TL, Hermone AR, Stafford RG, Lane DJ, Kenny TA, McGrath CF, Wipf P, Stahl AM, Schmidt JJ, Gussio R, Brunger AT, Bavari S. Burnett JC, et al. J Biol Chem. 2007 Feb 16;282(7):5004-5014. doi: 10.1074/jbc.M608166200. Epub 2006 Nov 8. J Biol Chem. 2007. PMID: 17092934 Free article.
SRC family kinase inhibitors antagonize the toxicity of multiple serotypes of botulinum neurotoxin in human embryonic stem cell-derived motor neurons.
Kiris E, Burnett JC, Nuss JE, Wanner LM, Peyser BD, Du HT, Gomba GY, Kota KP, Panchal RG, Gussio R, Kane CD, Tessarollo L, Bavari S. Kiris E, et al. Among authors: burnett jc. Neurotox Res. 2015 May;27(4):384-98. doi: 10.1007/s12640-015-9526-z. Epub 2015 Mar 18. Neurotox Res. 2015. PMID: 25782580 Free PMC article.
639 results