Nuss JE - Search Results

1

Three-dimensional database mining identifies a unique chemotype that unites structurally diverse botulinum neurotoxin serotype A inhibitors in a three-zone pharmacophore.

Hermone AR, Burnett JC, Nuss JE, Tressler LE, Nguyen TL, Solaja BA, Vennerstrom JL, Schmidt JJ, Wipf P, Bavari S, Gussio R. Hermone AR, et al. Among authors: nuss je. ChemMedChem. 2008 Dec;3(12):1905-12. doi: 10.1002/cmdc.200800241. ChemMedChem. 2008. PMID: 19006141

2

Pharmacophore-guided lead optimization: the rational design of a non-zinc coordinating, sub-micromolar inhibitor of the botulinum neurotoxin serotype a metalloprotease.

Burnett JC, Wang C, Nuss JE, Nguyen TL, Hermone AR, Schmidt JJ, Gussio R, Wipf P, Bavari S. Burnett JC, et al. Among authors: nuss je. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5811-3. doi: 10.1016/j.bmcl.2009.01.111. Epub 2009 Feb 13. Bioorg Med Chem Lett. 2009. PMID: 19703771

3

The synthesis of 2,5-bis(4-amidinophenyl)thiophene derivatives providing submicromolar-range inhibition of the botulinum neurotoxin serotype A metalloprotease.

Opsenica I, Filipovic V, Nuss JE, Gomba LM, Opsenica D, Burnett JC, Gussio R, Solaja BA, Bavari S. Opsenica I, et al. Among authors: nuss je. Eur J Med Chem. 2012 Jul;53:374-9. doi: 10.1016/j.ejmech.2012.03.043. Epub 2012 Mar 30. Eur J Med Chem. 2012. PMID: 22516424 Free PMC article.

4

Development of cell-based assays to measure botulinum neurotoxin serotype A activity using cleavage-sensitive antibodies.

Nuss JE, Ruthel G, Tressler LE, Wanner LM, Torres-Melendez E, Hale ML, Bavari S. Nuss JE, et al. J Biomol Screen. 2010 Jan;15(1):42-51. doi: 10.1177/1087057109354779. Epub 2009 Dec 4. J Biomol Screen. 2010. PMID: 19965805

5

Iterative structure-based peptide-like inhibitor design against the botulinum neurotoxin serotype A.

Zuniga JE, Hammill JT, Drory O, Nuss JE, Burnett JC, Gussio R, Wipf P, Bavari S, Brunger AT. Zuniga JE, et al. Among authors: nuss je. PLoS One. 2010 Jun 30;5(6):e11378. doi: 10.1371/journal.pone.0011378. PLoS One. 2010. PMID: 20614028 Free PMC article.

6

The osmolyte trimethylamine N-oxide (TMAO) increases the proteolytic activity of botulinum neurotoxin light chains A, B, and E: implications for enhancing analytical assay sensitivity.

Nuss JE, Wanner LM, Tressler LE, Bavari S. Nuss JE, et al. J Biomol Screen. 2010 Sep;15(8):928-36. doi: 10.1177/1087057110374996. Epub 2010 Aug 18. J Biomol Screen. 2010. PMID: 20720092

7

Pharmacophore Refinement Guides the Rational Design of Nanomolar-Range Inhibitors of the Botulinum Neurotoxin Serotype A Metalloprotease.

Nuss JE, Dong Y, Wanner LM, Ruthel G, Wipf P, Gussio R, Vennerstrom JL, Bavari S, Burnett JC. Nuss JE, et al. ACS Med Chem Lett. 2010 Oct 14;1(7):301-305. doi: 10.1021/ml100056v. ACS Med Chem Lett. 2010. PMID: 21116458 Free PMC article.

8

A chemotype that inhibits three unrelated pathogenic targets: the botulinum neurotoxin serotype A light chain, P. falciparum malaria, and the Ebola filovirus.

Opsenica I, Burnett JC, Gussio R, Opsenica D, Todorović N, Lanteri CA, Sciotti RJ, Gettayacamin M, Basilico N, Taramelli D, Nuss JE, Wanner L, Panchal RG, Solaja BA, Bavari S. Opsenica I, et al. Among authors: nuss je. J Med Chem. 2011 Mar 10;54(5):1157-69. doi: 10.1021/jm100938u. Epub 2011 Jan 25. J Med Chem. 2011. PMID: 21265542 Free PMC article.

9

Embryonic stem cell-derived motoneurons provide a highly sensitive cell culture model for botulinum neurotoxin studies, with implications for high-throughput drug discovery.

Kiris E, Nuss JE, Burnett JC, Kota KP, Koh DC, Wanner LM, Torres-Melendez E, Gussio R, Tessarollo L, Bavari S. Kiris E, et al. Among authors: nuss je. Stem Cell Res. 2011 May;6(3):195-205. doi: 10.1016/j.scr.2011.01.002. Epub 2011 Jan 19. Stem Cell Res. 2011. PMID: 21353660 Free PMC article.

10

Post-intoxication inhibition of botulinum neurotoxin serotype A within neurons by small-molecule, non-peptidic inhibitors.

Ruthel G, Burnett JC, Nuss JE, Wanner LM, Tressler LE, Torres-Melendez E, Sandwick SJ, Retterer CJ, Bavari S. Ruthel G, et al. Among authors: nuss je. Toxins (Basel). 2011 Mar;3(3):207-17. doi: 10.3390/toxins3030207. Epub 2011 Mar 15. Toxins (Basel). 2011. PMID: 22069707 Free PMC article.

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