Lefurgy ST - Search Results

1

Saturation mutagenesis of Asn152 reveals a substrate selectivity switch in P99 cephalosporinase.

Lefurgy ST, de Jong RM, Cornish VW. Lefurgy ST, et al. Protein Sci. 2007 Dec;16(12):2636-46. doi: 10.1110/ps.073092407. Protein Sci. 2007. PMID: 18029418 Free PMC article.

2

Structural analysis of the Asn152Gly mutant of P99 cephalosporinase.

Ruble JF, Lefurgy ST, Cornish VW, Powers RA. Ruble JF, et al. Among authors: lefurgy st. Acta Crystallogr D Biol Crystallogr. 2012 Sep;68(Pt 9):1189-93. doi: 10.1107/S0907444912024080. Epub 2012 Aug 18. Acta Crystallogr D Biol Crystallogr. 2012. PMID: 22948919

3

Finding Cinderella after the ball: a three-hybrid approach to drug target identification.

Lefurgy S, Cornish V. Lefurgy S, et al. Chem Biol. 2004 Feb;11(2):151-3. doi: 10.1016/j.chembiol.2004.02.005. Chem Biol. 2004. PMID: 15123273

4

Analysis of the Structure and Function of FOX-4 Cephamycinase.

Lefurgy ST, Malashkevich VN, Aguilan JT, Nieves E, Mundorff EC, Biju B, Noel MA, Toro R, Baiwir D, Papp-Wallace KM, Almo SC, Frere JM, Bou G, Bonomo RA. Lefurgy ST, et al. Antimicrob Agents Chemother. 2015 Nov 2;60(2):717-28. doi: 10.1128/AAC.01887-15. Print 2016 Feb. Antimicrob Agents Chemother. 2015. PMID: 26525784 Free PMC article.

5

Structures of FOX-4 Cephamycinase in Complex with Transition-State Analog Inhibitors.

Lefurgy ST, Caselli E, Taracila MA, Malashkevich VN, Biju B, Papp-Wallace KM, Bonanno JB, Prati F, Almo SC, Bonomo RA. Lefurgy ST, et al. Biomolecules. 2020 Apr 27;10(5):671. doi: 10.3390/biom10050671. Biomolecules. 2020. PMID: 32349291 Free PMC article.

6

A 13-week research-based biochemistry laboratory curriculum.

Lefurgy ST, Mundorff EC. Lefurgy ST, et al. Biochem Mol Biol Educ. 2017 Sep;45(5):437-448. doi: 10.1002/bmb.21054. Epub 2017 Mar 2. Biochem Mol Biol Educ. 2017. PMID: 28251763 Free article.

7

Alteration of substrate specificity of alanine dehydrogenase.

Fernandes P, Aldeborgh H, Carlucci L, Walsh L, Wasserman J, Zhou E, Lefurgy ST, Mundorff EC. Fernandes P, et al. Among authors: lefurgy st. Protein Eng Des Sel. 2015 Feb;28(2):29-35. doi: 10.1093/protein/gzu053. Epub 2014 Dec 23. Protein Eng Des Sel. 2015. PMID: 25538307 Free PMC article.

8

Probing the Mechanism of Inactivation of the FOX-4 Cephamycinase by Avibactam.

Nukaga M, Papp-Wallace KM, Hoshino T, Lefurgy ST, Bethel CR, Barnes MD, Zeiser ET, Johnson JK, Bonomo RA. Nukaga M, et al. Among authors: lefurgy st. Antimicrob Agents Chemother. 2018 Apr 26;62(5):e02371-17. doi: 10.1128/AAC.02371-17. Print 2018 May. Antimicrob Agents Chemother. 2018. PMID: 29439972 Free PMC article.

9

Probing ligand-binding pockets of the mevalonate pathway enzymes from Streptococcus pneumoniae.

Lefurgy ST, Rodriguez SB, Park CS, Cahill S, Silverman RB, Leyh TS. Lefurgy ST, et al. J Biol Chem. 2010 Jul 2;285(27):20654-63. doi: 10.1074/jbc.M109.098350. Epub 2010 Apr 19. J Biol Chem. 2010. PMID: 20404339 Free PMC article.

10

Analytical expressions for the homotropic binding of ligand to protein dimers and trimers.

Lefurgy ST, Leyh TS. Lefurgy ST, et al. Anal Biochem. 2012 Feb 15;421(2):433-8. doi: 10.1016/j.ab.2011.12.016. Epub 2011 Dec 16. Anal Biochem. 2012. PMID: 22230282 Free PMC article.

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