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Allosteric regulation of DNA binding and target residence time drive the cytotoxicity of phthalazinone-based PARP-1 inhibitors.
Arnold MR, Langelier MF, Gartrell J, Kirby IT, Sanderson DJ, Bejan DS, Šileikytė J, Sundalam SK, Nagarajan S, Marimuthu P, Duell AK, Shelat AA, Pascal JM, Cohen MS. Arnold MR, et al. Among authors: nagarajan s. Cell Chem Biol. 2022 Dec 15;29(12):1694-1708.e10. doi: 10.1016/j.chembiol.2022.11.006. Epub 2022 Dec 8. Cell Chem Biol. 2022. PMID: 36493759 Free article.
Ranolazine may exert its beneficial effects by increasing myocardial adenosine levels.
Le DE, Davis CM, Wei K, Zhao Y, Cao Z, Nugent M, Scott KLL, Liu L, Nagarajan S, Alkayed NJ, Kaul S. Le DE, et al. Among authors: nagarajan s. Am J Physiol Heart Circ Physiol. 2020 Jan 1;318(1):H189-H202. doi: 10.1152/ajpheart.00217.2019. Epub 2019 Dec 13. Am J Physiol Heart Circ Physiol. 2020. PMID: 31834840 Free PMC article.
Control of coronary vascular resistance by eicosanoids via a novel GPCR.
Alkayed NJ, Cao Z, Qian ZY, Nagarajan S, Liu X, Nelson JW, Xie F, Li B, Fan W, Liu L, Grafe MR, Davis CM, Xiao X, Barnes AP, Kaul S. Alkayed NJ, et al. Among authors: nagarajan s. Am J Physiol Cell Physiol. 2022 May 1;322(5):C1011-C1021. doi: 10.1152/ajpcell.00454.2021. Epub 2022 Apr 6. Am J Physiol Cell Physiol. 2022. PMID: 35385329 Free PMC article.
953 results