Binding site prediction of galanin peptide using evolutionary trace method

Shanthi Nagarajan; Parthiban Marimuthu

doi:10.6026/97320630001180

Binding site prediction of galanin peptide using evolutionary trace method

Bioinformation. 2006 Jul 25;1(5):180-3. doi: 10.6026/97320630001180.

Authors

Shanthi Nagarajan¹, Parthiban Marimuthu

Affiliation

¹ Bioinformatics Centre, Pondicherry University, Pondicherry, India.

Abstract

Galanin is a neuropeptide with aminoacid length ranging from 29 to 31 is widely distributed in central and peripheral nervous system. Galanin controls various psychological processes such as sensation of pain, learning, feeding, and sexual behaviour. The N-terminal region of this neuropeptide has highly conserved 15 amino acids, which is triggered by galanin receptors. We performed evolutionary trace analysis for galanin sequences to gather information about functional residues. The consensus pattern given by the evolutionary trace (ET) analysis is supported by CLUSTALW and WEBLOGO results. Our observations strongly suggest the presence of functional residues in the N-terminal region of galanin for agonist-receptor binding.