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MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 7: highly soluble and in vivo active quaternary ammonium analogue D13-9001, a potential preclinical candidate.
Yoshida K, Nakayama K, Ohtsuka M, Kuru N, Yokomizo Y, Sakamoto A, Takemura M, Hoshino K, Kanda H, Nitanai H, Namba K, Yoshida K, Imamura Y, Zhang JZ, Lee VJ, Watkins WJ. Yoshida K, et al. Among authors: takemura m. Bioorg Med Chem. 2007 Nov 15;15(22):7087-97. doi: 10.1016/j.bmc.2007.07.039. Epub 2007 Aug 22. Bioorg Med Chem. 2007. PMID: 17869116
Antimycobacterial activities of novel levofloxacin analogues.
Kawakami K, Namba K, Tanaka M, Matsuhashi N, Sato K, Takemura M. Kawakami K, et al. Among authors: takemura m. Antimicrob Agents Chemother. 2000 Aug;44(8):2126-9. doi: 10.1128/AAC.44.8.2126-2129.2000. Antimicrob Agents Chemother. 2000. PMID: 10898685 Free PMC article.
Design, synthesis and biological evaluations of novel 7-[3-(1-aminocycloalkyl)pyrrolidin-1-yl]-6-desfluoro-8-methoxyquinolones with potent antibacterial activity against multi-drug resistant Gram-positive bacteria.
Miyauchi R, Kawakami K, Ito M, Matsuhashi N, Ohki H, Inagaki H, Takahashi H, Takemura M. Miyauchi R, et al. Among authors: takemura m. Bioorg Med Chem. 2009 Oct 1;17(19):6879-89. doi: 10.1016/j.bmc.2009.08.026. Epub 2009 Aug 20. Bioorg Med Chem. 2009. PMID: 19736016
Synthesis and structure-activity relationships of 5-amino-6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-8-methylquinolonecarboxylic acid antibacterials having fluorinated 7-[(3R)-3-(1-aminocyclopropan-1-yl)pyrrolidin-1-yl] substituents.
Inagaki H, Miyauchi S, Miyauchi RN, Kawato HC, Ohki H, Matsuhashi N, Kawakami K, Takahashi H, Takemura M. Inagaki H, et al. Among authors: takemura m. J Med Chem. 2003 Mar 13;46(6):1005-15. doi: 10.1021/jm020328y. J Med Chem. 2003. PMID: 12620077
1,006 results