Abstract
A series of 4-oxo-4H-pyrido[1,2-a]pyrimidine derivatives, derivatized at the 2-position with carbon-linked substituents, were synthesized and evaluated for their ability to potentiate the activity of the fluoroquinolone levofloxacin (LVFX) and the anti-pseudomonas beta-lactam aztreonam (AZT) in Pseudomonas aeruginosa. Palladium-catalyzed cross-coupling methods were applied for the incorporation of aliphatic and aromatic substituents.
MeSH terms
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Anti-Bacterial Agents / chemical synthesis
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology
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Bacterial Outer Membrane Proteins / antagonists & inhibitors*
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Carbon / chemistry*
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Carbon / pharmacology*
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Drug Resistance, Bacterial / drug effects*
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Inhibitory Concentration 50
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Membrane Transport Proteins
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Microbial Sensitivity Tests
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Models, Chemical*
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Pseudomonas aeruginosa / drug effects*
Substances
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Anti-Bacterial Agents
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Bacterial Outer Membrane Proteins
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Membrane Transport Proteins
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MexA protein, Pseudomonas aeruginosa
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MexB protein, Pseudomonas aeruginosa
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Carbon