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Orally bioavailable highly potent HIV protease inhibitors against PI-resistant virus.
Bioorg Med Chem Lett. 2005 Dec 1;15(23):5311-4. doi: 10.1016/j.bmcl.2005.08.072. Epub 2005 Oct 3.
Bioorg Med Chem Lett. 2005.
PMID: 16203148
Design and synthesis of highly potent HIV protease inhibitors with activity against resistant virus.
Lu Z, Raghavan S, Bohn J, Charest M, Stahlhut MW, Rutkowski CA, Simcoe AL, Olsen DB, Schleif WA, Carella A, Gabryelski L, Jin L, Lin JH, Emini E, Chapman K, Tata JR.
Lu Z, et al. Among authors: simcoe al.
Bioorg Med Chem Lett. 2003 May 19;13(10):1821-4. doi: 10.1016/s0960-894x(03)00262-2.
Bioorg Med Chem Lett. 2003.
PMID: 12729673
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Inhibition of hepatitis C virus RNA replication by 2'-modified nucleoside analogs.
Carroll SS, Tomassini JE, Bosserman M, Getty K, Stahlhut MW, Eldrup AB, Bhat B, Hall D, Simcoe AL, LaFemina R, Rutkowski CA, Wolanski B, Yang Z, Migliaccio G, De Francesco R, Kuo LC, MacCoss M, Olsen DB.
Carroll SS, et al. Among authors: simcoe al.
J Biol Chem. 2003 Apr 4;278(14):11979-84. doi: 10.1074/jbc.M210914200. Epub 2003 Jan 27.
J Biol Chem. 2003.
PMID: 12554735
Free article.
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Replication fitness and NS5B drug sensitivity of diverse hepatitis C virus isolates characterized by using a transient replication assay.
Ludmerer SW, Graham DJ, Boots E, Murray EM, Simcoe A, Markel EJ, Grobler JA, Flores OA, Olsen DB, Hazuda DJ, LaFemina RL.
Ludmerer SW, et al.
Antimicrob Agents Chemother. 2005 May;49(5):2059-69. doi: 10.1128/AAC.49.5.2059-2069.2005.
Antimicrob Agents Chemother. 2005.
PMID: 15855532
Free PMC article.
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HIV-1 reverse transcriptase plus-strand initiation exhibits preferential sensitivity to non-nucleoside reverse transcriptase inhibitors in vitro.
Grobler JA, Dornadula G, Rice MR, Simcoe AL, Hazuda DJ, Miller MD.
Grobler JA, et al. Among authors: simcoe al.
J Biol Chem. 2007 Mar 16;282(11):8005-10. doi: 10.1074/jbc.M608274200. Epub 2006 Dec 15.
J Biol Chem. 2007.
PMID: 17172472
Free article.
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Identification of a key determinant of hepatitis C virus cell culture adaptation in domain II of NS3 helicase.
Grobler JA, Markel EJ, Fay JF, Graham DJ, Simcoe AL, Ludmerer SW, Murray EM, Migliaccio G, Flores OA.
Grobler JA, et al. Among authors: simcoe al.
J Biol Chem. 2003 May 9;278(19):16741-6. doi: 10.1074/jbc.M212602200. Epub 2003 Feb 28.
J Biol Chem. 2003.
PMID: 12615931
Free article.
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